John Roach

Frederick National Laboratory for Cancer Research — United States

Medicine · Health Sciences

12h-index564citations20works1.52yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(4), Microbial Natural Products and Biosynthesis(3), Fungal Biology and Applications(3), Protein purification and stability(3), CAR-T cell therapy research(3)

Publications20 total

Autologous CD33CART for Children and Adolescents/Young Adults with Relapsed/Refractory AML: Phase 1/2 Clinical Trial Correlative Biology Analyses Demonstrate Potent <i>in Vitro</i>, <i>In Vivo</i>, and <i>Ex Vivo</i> Anti-Leukemia Activity
Blood·2024
Success of Centralized Manufacturing of CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML
Transplantation and Cellular Therapy·2024· 3 cited
CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial
Blood·2023· 50 cited
Cholesterol and fats
Digital Collections of Colorado (Colorado State University)·2019Open Access
Purification of clinical-grade disulfide stabilized antibody fragment variable—Pseudomonas exotoxin conjugate (dsFv-PE38) expressed in Escherichia coli
Applied Microbiology and Biotechnology·2012· 15 cited
Paralytic shellfish toxins in clinical matrices: Extension of AOAC official method 2005.06 to human urine and serum and application to a 2007 case study in Maine
Deep Sea Research Part II Topical Studies in Oceanography·2012· 28 cited
Clinical manufacturing of recombinant human interleukin 15. I. Production cell line development and protein expression in <i>E. coli</i> with stop codon optimization
Biotechnology Progress·2011· 20 citedOpen Access
Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry
Chemical Research in Toxicology·2008· 37 citedOpen Access
Alkaloids and Saponins in Dietary Supplements of Blue Cohosh (Caulophyllum thalictroides)
Journal of AOAC International·2008· 12 citedOpen Access
Antioxidative Activity of Conjugated Linoleic Acid Determined by ESR
AOCS Publishing eBooks·2006· 1 cited
Preclinical Manufacture of an Anti-HER2 scFv-PEG-DSPE, Liposome-Inserting Conjugate. 1. Gram-Scale Production and Purification
Biotechnology Progress·2005· 86 cited
Production and purification of refolded recombinant human IL-7 from inclusion bodies
Protein Expression and Purification·2003· 32 cited
Methods Committee on Food Nutrition
Journal of AOAC International·2003Open Access
Production and Purification of a Recombinant Staphylococcal Enterotoxin B Vaccine Candidate Expressed in Escherichia coli
Protein Expression and Purification·2002· 36 cited
Committee on Food Nutrition
Journal of AOAC International·2002Open Access
Production of brefeldin-A
Journal of Industrial Microbiology & Biotechnology·1995· 22 citedOpen Access
Large scale production and semi-purification of kedarcidin in a 1000-L fermentor
Journal of Industrial Microbiology & Biotechnology·1994· 3 citedOpen Access
Improved processes for the production and isolation of dynemicin A and large-scale fermentation in a 10000-liter fermentor
Journal of Industrial Microbiology & Biotechnology·1992· 13 citedOpen Access
The Large-Scale Isolation of Bryostatin 1 from Bugula neritina Following Current Good Manufacturing Practices
Journal of Natural Products·1991· 157 cited
Chemistry of PCBs and PBBs
Environmental Health Perspectives·1978· 49 citedOpen Access

Frequent Co-authors

Jianwei Zhu(5), Steven L. Giardina(5), John T. Ross(4), William B. Lebherz(3), Salvatore Forenza(3), Nirali N. Shah(3), Sarah K. Tasian(3), Emily M. Hsieh(3), Susanne H.C. Baumeister(3), Bonnie Yates(3), Brian Bowser(3), George Mitra(3), Anthony Welch(3), Jason L. Yovandich(3), Rachelle Salomon(3), Katherine Tarlock(3), Michael R. Verneris(3), Steven M. Devine(3), Richard Aplenc(3), Magdi M. Mossoba(3)