M S Brown

Howard Hughes Medical Institute — United States

Medicine · Health Sciences

52h-index18.8kcitations58works0.02yr avg
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Research Topics

Cholesterol and Lipid Metabolism(20), Glycosylation and Glycoproteins Research(11), Cancer, Lipids, and Metabolism(10), Lipoproteins and Cardiovascular Health(9), Lipid metabolism and biosynthesis(9)

Publications58 total

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Molecular Cell·2000· 1.8k citedOpen Access
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
Molecular Cell·2000· 828 cited
Regulated Intramembrane Proteolysis
Cell·2000· 1.3k citedOpen Access
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
Journal of Clinical Investigation·1997· 443 citedOpen Access
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
Journal of Clinical Investigation·1997· 754 citedOpen Access
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
Journal of Clinical Investigation·1996· 815 citedOpen Access
Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.
Proceedings of the National Academy of Sciences·1996· 70 citedOpen Access
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.
Proceedings of the National Academy of Sciences·1996· 156 citedOpen Access
Low density lipoprotein receptor knockout mouse
Pathophysiology·1994Open Access
Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.
Proceedings of the National Academy of Sciences·1994· 60 citedOpen Access
A mitochondrial DNA (mtDNA) mutation associated with maternally inherited Parkinson`s disease (PD) and deafness
The American Journal of Human Genetics·1994· 2 cited
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
Proceedings of the National Academy of Sciences·1993· 611 citedOpen Access
cDNA Cloning of the Two Subunits of Human CAAX Farnesyltransferase and Chromosomal Mapping of FNTA and FNTB Loci and Related Sequences
Genomics·1993· 24 cited
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization
Journal of Biological Chemistry·1993· 297 citedOpen Access
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
Journal of Biological Chemistry·1992· 466 citedOpen Access
Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation.
Proceedings of the National Academy of Sciences·1992· 62 citedOpen Access
39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
Journal of Biological Chemistry·1991· 583 citedOpen Access
Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.
Proceedings of the National Academy of Sciences·1991· 314 citedOpen Access
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice.
The Journal of Cell Biology·1990· 107 citedOpen Access
Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.
Journal of Clinical Investigation·1990· 193 citedOpen Access
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Frequent Co-authors

J L Goldstein(17), Joseph L. Goldstein(17), J L Goldstein(14), Y K Ho(7), Robert E. Hammer(5), R G Anderson(5), J R Faust(5), Iichiro Shimomura(4), Hitoshi Shimano(3), Jay D. Horton(3), Joachim Herz(3), Richard D. Cummings(3), Wolfgang J. Schneider(3), David W. Russell(3), S. Basu(3), David W. Bilheimer(3), Daniel J. Chin(3), K L Luskey(3), Robert B. Rawson(2), Joseph L Goldstein(2)