Jianming Bao

Roche (China) — China

Chemistry · Physical Sciences

17h-index1.2kcitations35works4.02yr avg
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Research Topics

Asymmetric Synthesis and Catalysis(5), Synthetic Organic Chemistry Methods(5), Cardiac electrophysiology and arrhythmias(4), Ion channel regulation and function(4), Cyclopropane Reaction Mechanisms(4)

Publications35 total

Abstract 239: RCZY-690 and RCZY-680: Novel, highly potent, and orally bioavailable, tri-complex pan RAS-MULTI(ON) inhibitors with distinctive oral pharmacokinetic profiles, exhibiting broad anti-tumor activities in CDX models
Cancer Research·2025· 1 cited
Abstract 1419: RCZY-711, a novel, highly potent, and orally bioavailable menin-MLL inhibitor with superior efficacy in preclinical acute leukemia models
Cancer Research·2025· 1 cited
Discovery and Evaluation of TLR-Targeted Immune Agonists
Journal of Medicinal Chemistry·2024· 5 cited
Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads
Journal of Medicinal Chemistry·2024· 9 cited
Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α
Journal of Medicinal Chemistry·2022· 3 citedOpen Access
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties
Journal of Medicinal Chemistry·2021· 16 citedOpen Access
Mild Condition for the Deoxygenation of α-Heteroaryl-Substituted Methanol Derivatives
The Journal of Organic Chemistry·2021· 4 cited
Scalable Preparation of 4,4-Disubstituted Six-Membered Cyclic Sulfones
Organic Letters·2021· 11 cited
A General One-Pot Protocol for Hindered <i>N</i>-Alkyl Azaheterocycles from Tertiary Carboxylic Acids
Organic Letters·2020· 16 cited
Selective N7 Alkylation of 7-Azaindazoles
The Journal of Organic Chemistry·2020· 4 cited
Discovery of [<sup>11</sup>C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases
Journal of Medicinal Chemistry·2020· 39 citedOpen Access
A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
Nature Communications·2019· 64 citedOpen Access
Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists
ACS Medicinal Chemistry Letters·2018· 6 citedOpen Access
A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications
Bioconjugate Chemistry·2018· 59 cited
V–P–O compound encapsulated palladium nanoparticles supported on carbon nanotubes as a methanol-tolerant oxygen reduction electrocatalyst
RSC Advances·2016· 2 cited
Composition-Dependent Electrocatalytic Activity of Palladium–Iridium Binary Alloy Nanoparticles Supported on the Multiwalled Carbon Nanotubes for the Electro-Oxidation of Formic Acid
ACS Applied Materials & Interfaces·2015· 36 cited
2-[(3a<i>R</i>,4<i>R</i>,5<i>S</i>,7a<i>S</i>)-5-{(1<i>S</i>)-1-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2<i>H</i>-isoindol-2-yl]-1,3-oxazol-4(5<i>H</i>)-one: A Potent Human NK<sub>1</sub> Receptor Antagonist with Multiple Clearance Pathways
Journal of Medicinal Chemistry·2013· 11 citedOpen Access
Tetrahydroindolizinone NK1 antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 6 citedOpen Access
p38 MAP Kinase Inhibitors: Metabolically Stabilized Piperidine‐Substituted Quinolinones and Naphthyridinones.
ChemInform·2006· 1 cited
p38 MAP kinase inhibitors: Metabolically stabilized piperidine-substituted quinolinones and naphthyridinones
Bioorganic & Medicinal Chemistry Letters·2005· 10 citedOpen Access
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Frequent Co-authors

William D. Wulff(7), Kathleen M. Rupprecht(7), William H. Parsons(6), Frank Kayser(5), Gregory J. Kaczorowski(5), Shouwu Miao(5), María L. García(4), Robert S. Slaughter(4), Gloria C. Koo(4), Mary Jo Staruch(4), Joseph Duffy(4), Arnold L. Rheingold(3), John P. Felix(3), Randal M. Bugianesi(3), William A. Schmalhofer(3), Kashmira Shah(3), Robert K. Baker(3), Xinchun Tong(3), Peter M. Sinclair(3), George A. Doss(3)