Mary Jo Staruch

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index3.2kcitations42works0.02yr avg
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Research Topics

Signaling Pathways in Disease(19), Cancer therapeutics and mechanisms(7), Synthesis and Biological Evaluation(6), NF-κB Signaling Pathways(5), Peptidase Inhibition and Analysis(5)

Publications42 total

Potent Kv1.3 inhibitors from correolide—modification of the C18 position
Bioorganic & Medicinal Chemistry Letters·2004· 20 citedOpen Access
Substitution of a Single Residue in <i>Stichodactyla helianthus</i> Peptide, ShK-Dap<sup>22</sup>, Reveals a Novel Pharmacological Profile
Biochemistry·2003· 28 cited
Benzamide derivatives as blockers of Kv1.3 ion channel
Bioorganic & Medicinal Chemistry Letters·2003· 30 citedOpen Access
Identification of a New Class of Inhibitors of the Voltage-Gated Potassium Channel, K<sub>v</sub>1.3, with Immunosuppressant Properties
Biochemistry·2002· 64 cited
CCR5, CXCR4, and CD4 Are Clustered and Closely Apposed on Microvilli of Human Macrophages and T Cells
Journal of Virology·2001· 160 citedOpen Access
Correolide and Derivatives Are Novel Immunosuppressants Blocking the Lymphocyte Kv1.3 Potassium Channels
Cellular Immunology·1999· 81 cited
Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation
Immunopharmacology·1999· 24 cited
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study
Bioorganic & Medicinal Chemistry Letters·1999· 3 citedOpen Access
A Specific Inhibitor of the p38 Mitogen Activated Protein Kinase Affects Differentially the Production of Various Cytokines by Activated Human T Cells: Dependence on CD28 Signaling and Preferential Inhibition of IL-10 Production
Cellular Immunology·1999· 74 cited
Distinctive Calcineurin-Dependent (FK506-Sensitive) Mechanisms Regulate the Production of the CC Chemokines Macrophage Inflammatory Protein (MIP)-1α, MIP-1β, and RANTES vs IL-2 and TNF-α by Activated Human T Cells
Cellular Immunology·1998· 22 cited
C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential
Bioorganic & Medicinal Chemistry Letters·1998· 13 citedOpen Access
Binding and Functional Properties of Recombinant and Endogenous CXCR3 Chemokine Receptors
Journal of Biological Chemistry·1998· 215 citedOpen Access
Inhibition of T Cell Activation by Pharmacologic Disruption of the MEK1/ERK MAP Kinase or Calcineurin Signaling Pathways Results in Differential Modulation of Cytokine Production
The Journal of Immunology·1998· 187 citedOpen Access
ChemInform Abstract: C32‐Amino Derivatives of the Immunosuppressant Ascomycin.
ChemInform·1998
A TACROLIMUS-RELATED IMMUNOSUPPRESSANT WITH REDUCED TOXICITY
Transplantation·1998· 26 cited
C32-amino derivatives of the immunosuppressant ascomycin
Bioorganic & Medicinal Chemistry Letters·1997· 7 cited
ChemInform Abstract: Preparation and in vitro Activities of Naphthyl and Indolyl Ether Derivatives of the FK‐506 Related Immunosuppressive Macrolide Ascomycin.
ChemInform·1997
Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin
Bioorganic & Medicinal Chemistry Letters·1996· 37 cited
Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization.
Journal of Pharmacology and Experimental Therapeutics·1996· 4 cited
Dominant Mutations Confer Resistance to the Immunosuppressant, Rapamycin, in Variants of a T Cell Lymphoma
Cellular Immunology·1995· 33 cited
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Frequent Co-authors

Francis J. Dumont(26), Matthew J. Wyvratt(11), William H. Parsons(10), David D. Wood(9), Peter M. Sinclair(7), Sam L. Koprak(6), N H Sigal(5), Paul Fischer(5), Gloria C. Koo(5), Kathleen M. Rupprecht(5), Gregory J. Kaczorowski(5), Frederick Wong(5), Mark T. Goulet(5), John J. Siekierka(4), Jianming Bao(4), Robert S. Slaughter(4), María L. García(4), Michael Melino(3), Martin S. Springer(3), Carolyn DaSilva(3)