N H Sigal

Stanford University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index7.5kcitations93works1.02yr avg
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Research Topics

Signaling Pathways in Disease(29), Monoclonal and Polyclonal Antibodies Research(21), T-cell and B-cell Immunology(20), Immune Cell Function and Interaction(14), Peptidase Inhibition and Analysis(12)

Publications93 total

Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with <i>Plasmodium falciparum</i>
Science Translational Medicine·2025· 1 citedOpen Access
Surfing the piperazine core of tricyclic farnesyltransferase inhibitors
Bioorganic & Medicinal Chemistry Letters·2005· 33 citedOpen Access
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry
Proceedings of the National Academy of Sciences·2000· 200 citedOpen Access
Small molecule antagonists of the bradykinin B1 receptor
Immunopharmacology·1999· 29 cited
Combinatorial Chemistry: Part of the Evolution in Drug Discovery
1999· 1 cited
Applying informatics systems to high-throughput screening and analysis
Trends in biotechnology·1999· 8 cited
A TACROLIMUS-RELATED IMMUNOSUPPRESSANT WITH BIOCHEMICAL PROPERTIES DISTINCT FROM THOSE OF TACROLIMUS
Transplantation·1998· 27 cited
A TACROLIMUS-RELATED IMMUNOSUPPRESSANT WITH REDUCED TOXICITY
Transplantation·1998· 26 cited
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo
The Journal of Immunology·1997· 217 citedOpen Access
Biological Screening of a Large Combinatorial Library
SLAS DISCOVERY·1996· 26 citedOpen Access
A paradigm for drug discovery employing encoded combinatorial libraries.
Proceedings of the National Academy of Sciences·1995· 92 citedOpen Access
Binary encoded small-molecule libraries in drug discovery and optimization
Perspectives in Drug Discovery and Design·1995· 17 citedOpen Access
Immunosuppression
Perspectives in Drug Discovery and Design·1994· 1 cited
The Mechanism of Action of FK‐506 and Cyclosporin A
Annals of the New York Academy of Sciences·1993· 347 cited
FK‐506–A Novel Immunosuppressant
Annals of the New York Academy of Sciences·1993· 50 cited
Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.
The Journal of Experimental Medicine·1993· 238 citedOpen Access
A single administration of LFA-1 antibody confers prolonged allograft survival.
PubMed·1993· 31 cited
Recent advances in the mechanism of action of cyclosporine and FK506
Current Opinion in Nephrology & Hypertension·1992· 16 cited
ChemInform Abstract: Chemistry and Biology of the Immunosuppressant (‐)‐FK‐506
ChemInform·1992
FK-506 and cyclosporin A: Immunosuppressive mechanism of action and beyond
Current Biology·1992· 3 cited
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Frequent Co-authors

John J. Siekierka(11), Norman R. Klinman(9), Patricia J. Gearhart(7), Francis J. Dumont(6), Greg Wiederrecht(5), G C Koo(5), John J. Baldwin(5), Mary Jo Staruch(4), Mary M. Martin(4), Joseph T. Blake(4), Daniel Chelsky(4), Leonard D. Stein(4), Shirley H.Y. Hung(3), Martin Poe(3), C. Shirley Lin(3), Sam L. Koprak(3), Michael Melino(3), Laurence B. Peterson(3), Robert C. Boltz(3), Althea Talento(3)