Patricia J. Gearhart

National Institutes of Health — United States

Immunology and Microbiology · Life Sciences

50h-index7.8kcitations163works0.32yr avg
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Research Topics

T-cell and B-cell Immunology(78), Immune Cell Function and Interaction(46), Monoclonal and Polyclonal Antibodies Research(44), DNA Repair Mechanisms(39), Immunotherapy and Immune Responses(19)

Publications163 total

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia
Scientific Reports·2025Open Access
Sex differences in B cell dynamics after seasonal influenza vaccination are dependent on the age and hormonal status of vaccinees 3346
The Journal of Immunology·2025Open Access
Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia
2025Open Access
Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia
2025Open Access
Estrogen upregulates NF-κB and TNF signaling in B cells to cause sex and age differences in antibody responses to seasonal influenza vaccination
2025· 1 citedOpen Access
Aging’s impact on the immune system
The Journal of Immunology·2025
Optimized CUT&RUN protocol for activated primary mouse B cells
PLoS ONE·2025· 1 citedOpen Access
F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death
UNC Libraries·2024Open Access
Establishing novel and unique technology to uncover how Activation-Induced Deaminase specifically targets immunoglobulin regions
The Journal of Immunology·2023Open Access
Unmasking Arterial-resident Autoreactive B cells involved in Atherosclerosis and Peripheral Artery Disease Progression
The Journal of Immunology·2023Open Access
Sex and age differences in B cell frequencies and antibody responses following influenza vaccination in highly vaccinated adult populations
The Journal of Immunology·2023Open Access
Pre-activation of follicular B cells in old mice generates a hyper-response during germinal center reaction
The Journal of Immunology·2023· 1 citedOpen Access
B cell dysfunction during aging is not dependent on stem cell aging
The Journal of Immunology·2023· 1 citedOpen Access
The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
Frontiers in Immunology·2023· 4 citedOpen Access
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis
Immunity & Ageing·2022· 17 citedOpen Access
The IgH <i>Eμ</i> -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
2022· 2 citedOpen Access
Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells
mBio·2022· 37 citedOpen Access
Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells
2022· 2 citedOpen Access
Follicular B cells from old mice are hyper-responsive and produce non-specific antibodies.
The Journal of Immunology·2022
Sex differences in B cell frequencies and antibody responses following influenza vaccination in healthcare workers during the 2019–2020 season
The Journal of Immunology·2022
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Frequent Co-authors

Robert W. Maul(10), David B. Winter(6), William Yang(5), N H Sigal(5), Norman R. Klinman(5), Stella Martomo(4), Quy H. Phung(4), John J. Cebra(4), Fumio Hanaoka(3), Roger Woodgate(3), Robert E. Tarone(3), Vilhelm A. Bohr(3), Richard D. Wood(3), Huseyin Saribasak(3), Rhonda L. McClure(3), Kathryn A. Pape(2), Marc K. Jenkins(2), Nelson D. Johnson(2), R. Douglas(2), Leroy Hood(2)