Kent L. Kunze

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

56h-index10.1kcitations117works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(75), Drug Transport and Resistance Mechanisms(25), Analytical Chemistry and Chromatography(15), Porphyrin Metabolism and Disorders(15), Pharmacological Effects and Toxicity Studies(14)

Publications117 total

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test
Carolina Digital Repository (University of North Carolina at Chapel Hill)·2019· 305 citedOpen Access
Self-catalyzed destruction of cytocl ethynyl sterols to prosthetic heme (biooxidation/porphyrins/green pigment/acetylene metabolism)
2016
N-Methylprotoporphyrin IX: Chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4- dihydrocollidine treatment (N-alkyl porphyrins/porphyrin synthesis/ferrochelatase inhibitor/NMR)
2016
Head Rotation Evoked EEG Responses Are Governed by Rate of Angular Acceleration Change
Advances in oto-rhino-laryngology·2015
Distal Latencies of Single Evoked Motor Units in Normal and Neuropathic Subjects
2015
Morphology, Histochemistry and Biochemistry and Electrophysiology in Neuromuscular Diseases
2015
Characterization of Ritonavir-Mediated Inactivation of Cytochrome P450 3A4
Molecular Pharmacology·2014· 93 cited
Fluoxetine- and Norfluoxetine-Mediated Complex Drug–Drug Interactions: In Vitro to In Vivo Correlation of Effects on CYP2D6, CYP2C19, and CYP3A4
Clinical Pharmacology & Therapeutics·2014· 79 citedOpen Access
Characterization of Ritonavir-Mediated Inactivation of Cytochrome P450 3A4 s
2014· 1 cited
Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
Drug Metabolism and Disposition·2013· 14 citedOpen Access
Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
Drug Metabolism and Disposition·2013· 29 citedOpen Access
Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time- Dependent Inhibitor Systems s
2013· 1 cited
Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions
Drug Metabolism and Disposition·2012· 15 citedOpen Access
Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
Drug Metabolism and Disposition·2011· 30 citedOpen Access
Allosteric Activation of Cytochrome P450 3A4 by α-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis
Biochemistry·2011· 42 cited
Evaluation of 6β-Hydroxycortisol, 6β-Hydroxycortisone, and a Combination of the Two as Endogenous Probes for Inhibition of CYP3A4 In Vivo
Clinical Pharmacology & Therapeutics·2011· 69 citedOpen Access
Metabolism of Diltiazem: A Short Efficient Synthesis of N,N-Didesmethyldiltiazem - An Important Product of N-Demethylation
Synthesis·2011
Accurate Prediction of Dose-Dependent CYP3A4 Inhibition by Itraconazole and Its Metabolites From In Vitro Inhibition Data
Clinical Pharmacology & Therapeutics·2010· 68 citedOpen Access
Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, (S)-Fluoxetine, and N-Desmethyldiltiazem
Drug Metabolism and Disposition·2010· 45 citedOpen Access
Crystral Structure of the nucleoporin Nic96
2007
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Frequent Co-authors

Kenneth E. Thummel(23), Danny D. Shen(9), P.R. Ortiz de Montellano(9), William Trager(6), W. Trager(6), Nina Isoherranen(6), Larry C. Wienkers(6), Christopher L. Marsh(5), James D. Perkins(5), Hal S. Beilan(5), Mary F. Paine(4), Terry Podoll(4), John P. McVicar(4), Darlene Barr(4), Allan E. Rettie(3), A. Craig Eddy(3), Steven Wrighton(3), Kyle E. Allen(3), David L. Eaton(3), Evan P. Gallagher(3)