Yoichi Osawa

University of Michigan–Ann Arbor — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index5.5kcitations136works1.02yr avg
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Research Topics

Heat shock proteins research(42), Nitric Oxide and Endothelin Effects(26), Hemoglobin structure and function(21), Pharmacogenetics and Drug Metabolism(19), Mitochondrial Function and Pathology(15)

Publications134 total

Computational design of CYP102A1 variants for the biosynthesis of a next-generation antiplatelet drug DT-678
2025· 1 citedOpen Access
Development of Nanobodies and Truncated Heterodimers of nNOS as Approaches for Biochemical and Structural Analysis (Abstract ID: 161582)
Journal of Pharmacology and Experimental Therapeutics·2025
High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase
Molecular Pharmacology·2024· 3 citedOpen Access
Bacterial expression, purification, and characterization of human cytochrome P450 3A4 without N-terminal modifications
Archives of Biochemistry and Biophysics·2024
A General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library
Biomedicines·2024· 1 citedOpen Access
Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry
Journal of Biological Chemistry·2023· 10 citedOpen Access
Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign
Journal of Biological Chemistry·2023· 16 citedOpen Access
The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering
Molecules·2023· 8 citedOpen Access
Pharmacological Modulation of Hsp70 to Selectively Remove Misfolded Neuronal Nitric Oxide Synthase
Journal of Pharmacology and Experimental Therapeutics·2023Open Access
Data from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Methods from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Table IV from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Methods from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Table III from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Table II from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Table I from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Table IV from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Table I from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Figure from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
Supplementary Table III from Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
2023Open Access
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Frequent Co-authors

William B. Pratt(16), Yoshihiro Morishima(13), Hwei‐Ming Peng(7), Andrew T. Bender(6), Andrew P. Lieberman(5), Damon R. Demady(5), Jennifer L. Vuletich(4), Ezra R. Lowe(4), Scott S. Billecke(4), Anwar Y. Dunbar(4), Roger K. Sunahara(3), Jason E. Gestwicki(3), Kimon C. Kanelakis(3), Soichi Noguchi(3), Suree Jianmongkol(3), Paul F. Hollenberg(3), Patrick J. Murphy(3), Gary J. Jenkins(3), Yasuhiko Kamada(3), Miranda Lau(3)