Susan M. Freier

Ionis Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

56h-index20.2kcitations146works5.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(60), RNA and protein synthesis mechanisms(42), RNA Research and Splicing(32), RNA modifications and cancer(31), Cancer-related molecular mechanisms research(26)

Publications145 total

Chromatin-associated lncRNA-splicing factor condensates regulate hypoxia responsive RNA processing of genes pre-positioned near nuclear speckles
2024· 5 citedOpen Access
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
Cell·2023· 17 citedOpen Access
Antisense oligonucleotides to therapeutically target SARS-CoV-2 infection
PLoS ONE·2023· 19 citedOpen Access
Methods of obtaining active antisense compounds
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2023Open Access
Monoallelically-expressed Noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression
2022· 1 citedOpen Access
Antagonism between splicing and microprocessor complex dictates the serum-induced processing of lnc-<i>MIRHG</i> for efficient cell cycle reentry
RNA·2020· 16 citedOpen Access
2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance
Haematologica·2020· 2 citedOpen Access
Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy
Nucleic Acid Therapeutics·2020· 30 citedOpen Access
2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies
Blood·2019
Abstract 3573: Identification and functional characterization of prognostic long non coding RNA LADDER in lung cancer
Molecular and Cellular Biology / Genetics·2019
Abstract 3573: Identification and functional characterization of prognostic long non coding RNA LADDER in lung cancer
Cancer Research·2019
A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability
PLoS Genetics·2018· 141 citedOpen Access
MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs
Nucleic Acids Research·2018· 79 citedOpen Access
Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression
Nature Genetics·2018· 237 cited
Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution
Journal of Cell Science·2017· 312 citedOpen Access
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
Cell·2017· 250 citedOpen Access
Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines
Human Molecular Genetics·2016· 11 citedOpen Access
Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration
Cell Reports·2016· 62 citedOpen Access
Identification and Validation of PCAT14 as Prognostic Biomarker in Prostate Cancer
Neoplasia·2016· 94 citedOpen Access
Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer
Oncotarget·2016· 158 citedOpen Access
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Frequent Co-authors

Douglas H. Turner(12), C. Frank Bennett(9), Kannanganattu V. Prasanth(7), Brett P. Monia(7), Ryszard Kierzek(7), Andrew T. Watt(6), Supriya G. Prasanth(6), Elena A. Lesnik(6), Thomas Neilson(5), David J. Ecker(5), Eric E. Swayze(5), Naoki Sugimoto(4), Marvin H. Caruthers(4), Jacqueline R. Wyatt(4), Gene Hung(4), Shuling Guo(4), Henri Sasmor(4), Vidisha Tripathi(3), Christine Esau(3), Ashish Lal(3)