Andrew T. Watt

Ionis Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index4.5kcitations35works2.02yr avg
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Research Topics

RNA Research and Splicing(8), DNA and Nucleic Acid Chemistry(7), RNA and protein synthesis mechanisms(6), Advanced biosensing and bioanalysis techniques(4), Cancer-related molecular mechanisms research(4)

Publications35 total

Tuning siRNA Specificity through Seed Region Incorporation of Deoxyribonucleotide Stereoisomers
2026Open Access
Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile
Nucleic Acids Research·2025· 4 citedOpen Access
Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice
Molecular Therapy·2022· 14 citedOpen Access
Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer
Journal for ImmunoTherapy of Cancer·2022· 77 citedOpen Access
Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy
Nucleic Acid Therapeutics·2020· 30 citedOpen Access
Abstract 3573: Identification and functional characterization of prognostic long non coding RNA LADDER in lung cancer
Cancer Research·2019
Antisense oligonucleotide treatment ameliorates IFN-γ–induced proteinuria in APOL1-transgenic mice
JCI Insight·2019· 99 citedOpen Access
Abstract 5561: High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T-cells and produce antitumor effects in syngeneic tumor models
Cancer Research·2018· 7 cited
Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression
Nature Genetics·2018· 237 cited
LO20: Emergency department initiated drug therapy and patient compliance in acute renal colic
Canadian Journal of Emergency Medicine·2018Open Access
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice
Hepatology Communications·2017· 48 citedOpen Access
Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus nephritis in mice
Immunobiology·2015· 32 citedOpen Access
Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio- and C5- Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides
Nucleic Acid Therapeutics·2015· 38 cited
Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency
PLoS ONE·2014· 16 citedOpen Access
Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients
PLoS ONE·2014· 112 citedOpen Access
In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides
Molecular Therapy·2014· 145 citedOpen Access
Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease
Rare Diseases·2014· 19 citedOpen Access
Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin–related liver disease in mice
Journal of Clinical Investigation·2013· 80 cited
Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration
Proceedings of the National Academy of Sciences·2013· 551 citedOpen Access
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Nucleic Acids Research·2013· 158 citedOpen Access
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Frequent Co-authors

Susan M. Freier(12), Eric E. Swayze(9), Punit P. Seth(6), Sheri Booten(6), Brett P. Monia(6), C. Frank Bennett(4), Shuling Guo(4), Michael E. Østergaard(4), Mariam Aghajan(4), Danielle Gattis(4), Michael L. McCaleb(4), Amber L. Southwell(3), Holly Kordasiewicz(3), Niels H. Skotte(3), Crystal N. Doty(3), Kuljeet Vaid(3), Michael R. Hayden(3), Gene Hung(3), Charles Allerson(3), Andrés Berdeja(3)