Matthew Bridgland‐Taylor

AstraZeneca (United Kingdom) — United Kingdom

Medicine · Health Sciences

8h-index687citations16works0.02yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(12), Ion channel regulation and function(6), Neuroscience and Neural Engineering(3), Cardiac Imaging and Diagnostics(2), Cardiac pacing and defibrillation studies(2)

Publications16 total

Mutations of the nACh Receptor M4 Helix Reveal Different Phenotypes in Different Expression Systems: Could Lipids be Responsible?
Frontiers in Physiology·2022· 4 citedOpen Access
Translational understanding of PDE4 inhibition
Journal of Pharmacological and Toxicological Methods·2021
Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells
Scientific Reports·2020· 3 citedOpen Access
Corrigendum to “A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm” [Toxicology and Applied Pharmacology volume 394C (2020) 114961]
Toxicology and Applied Pharmacology·2020· 2 citedOpen Access
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells
Scientific Reports·2020· 59 citedOpen Access
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm
Toxicology and Applied Pharmacology·2020· 45 citedOpen Access
Mechanistic investigation into a delayed onset QTc prolongation
Journal of Pharmacological and Toxicological Methods·2016
A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm
SLAS DISCOVERY·2015· 303 citedOpen Access
Evaluation of drug‐induced<scp>QT</scp>interval prolongation in animal and human studies: a literature review of concordance
British Journal of Pharmacology·2015· 55 citedOpen Access
Effect of mutating amino acids considered critical for hERG channel blocker activity on the profile of a hERG channel activator
Journal of Pharmacological and Toxicological Methods·2014
Prediction of Thorough QT study results using action potential simulations based on ion channel screens
Journal of Pharmacological and Toxicological Methods·2014· 96 citedOpen Access
Prediction and Modeling of Effects on the QTc Interval for Clinical Safety Margin Assessment, Based on Single-Ascending-Dose Study Data with AZD3839
Journal of Pharmacology and Experimental Therapeutics·2014· 14 cited
A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans
Toxicological Sciences·2013· 75 cited
Cardiac contractility assessment: A case study with clear impact and relevance of preclinical data
Journal of Pharmacological and Toxicological Methods·2012· 2 cited
Validation of a cardiac L-type calcium channel assay using IonWorks™
Journal of Pharmacological and Toxicological Methods·2010· 4 cited
Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes
Journal of Pharmacological and Toxicological Methods·2009· 25 cited

Frequent Co-authors

John P. Imredy(5), James Kramer(5), Anders Lindqvist(5), Najah Abi‐Gerges(4), Herbert M. Himmel(4), Sonja Stoelzle‐Feix(4), Simon Hebeisen(4), Jing‐Song Fan(4), Muthukrishnan Renganathan(4), Edward Humphries(4), Nina Brinkwirth(4), Tim Strassmaier(4), Timm Danker(4), Liudmila Polonchuk(4), Jean‐Pierre Valentin(4), Chris Pollard(4), Bernard Fermini(3), Khuram W. Chaudhary(3), Gary A. Gintant(3), Paul Lévesque(3)