Zhongren Wu

China Three Gorges University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index470citations27works1.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(10), Renin-Angiotensin System Studies(7), Virus-based gene therapy research(5), Viral Infectious Diseases and Gene Expression in Insects(4), Mass Spectrometry Techniques and Applications(3)

Publications26 total

Research on low carbon welding scheduling based on production process
Scientific Reports·2024· 1 citedOpen Access
A Robust System for Production of Superabundant VP1 Recombinant AAV Vectors
Molecular Therapy — Methods & Clinical Development·2017· 37 citedOpen Access
Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors
Molecular Therapy — Methods & Clinical Development·2016· 13 citedOpen Access
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core
Bioorganic & Medicinal Chemistry Letters·2016· 10 citedOpen Access
High-Density Recombinant Adeno-Associated Viral Particles are Competent Vectors for <i>In Vivo</i> Transduction
Human Gene Therapy·2016· 17 citedOpen Access
545. Syngeneic AAV Pseudo-Vectors Potentiates Full Vector Transduction
Molecular Therapy·2016Open Access
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist
Journal of Medicinal Chemistry·2016· 32 citedOpen Access
558. Second Generation Vaccinia Carrier for Scalable and Efficient Production of Recombinant AAV Vectors
Molecular Therapy·2015Open Access
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility
ACS Medicinal Chemistry Letters·2011· 38 citedOpen Access
Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket
Bioorganic & Medicinal Chemistry Letters·2011· 8 citedOpen Access
Clinically Useful Alkyl Amine Renin Inhibitors
2010
Alkyl Amine Renin Inhibitors: Filling S1 from S3
2010
Optimization of orally bioavailable alkyl amine renin inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 18 citedOpen Access
Design and optimization of renin inhibitors: Orally bioavailable alkyl amines
Bioorganic & Medicinal Chemistry Letters·2009· 18 citedOpen Access
Purification and characterization of recombinant human renin for X-ray crystallization studies
BMC Biochemistry·2008· 10 citedOpen Access
Purification and characterization of recombinant human cathepsin E expressed in human kidney cell line 293
Protein Expression and Purification·2004· 6 cited
UV Crosslinking of Adrenergic Receptors and Ligands: Detection by SDS-PAGE
Humana Press eBooks·2003· 2 cited
Hepatitis C Virus NS3 Protease Requires Its NS4A Cofactor Peptide for Optimal Binding of a Boronic Acid Inhibitor as Shown by NMR
Chemistry & Biology·2002· 25 citedOpen Access
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α
Proceedings of the National Academy of Sciences·2001· 136 citedOpen Access
Tyr199 in transmembrane domain 5 of the β2-adrenergic receptor interacts directly with the pharmacophore of a unique fluorenone-based antagonist
Biochemical Journal·2001· 10 citedOpen Access
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Frequent Co-authors

Gerard M. McGeehan(8), Brian M. McKeever(7), Yuri Bukhtiyarov(7), Wei Zhao(6), Colin M. Tice(6), Joan Guo(6), Suresh B. Singh(6), David A. Claremon(6), Richard K. Harrison(5), Qizhao Wang(5), Weidong Xiao(5), Boyd B. Scott(5), R. David Simpson(4), Jing Yuan(4), Zhenrong Xu(4), Salvacion Cacatian(4), Alexey Ishchenko(4), Lawrence W. Dillard(4), John J. Baldwin(4), Jenni Firrman(4)