David Waterson

Medicines for Malaria Venture — Switzerland

Medicine · Health Sciences

34h-index3.2kcitations77works0.02yr avg
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Research Topics

Malaria Research and Control(25), HIV/AIDS drug development and treatment(19), Computational Drug Discovery Methods(16), Phenothiazines and Benzothiazines Synthesis and Activities(12), Biochemical and Molecular Research(9)

Publications77 total

Optimization of diastereomeric dihydropyridines as antimalarials
European Journal of Medicinal Chemistry·2024
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as <i>Pf</i>eEF2
ChemMedChem·2022· 9 citedOpen Access
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria
Journal of Medicinal Chemistry·2020· 35 citedOpen Access
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
ChemMedChem·2019· 7 citedOpen Access
Erratum for Brunschwig et al., “UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria”
Antimicrobial Agents and Chemotherapy·2018· 14 citedOpen Access
Isoxazolopyrimidine-Based Inhibitors of <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase with Antimalarial Activity
ACS Omega·2018· 32 citedOpen Access
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria
Antimicrobial Agents and Chemotherapy·2018· 136 citedOpen Access
Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal·2017· 18 citedOpen Access
Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase
Science Translational Medicine·2017· 262 citedOpen Access
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle
Journal of Medicinal Chemistry·2016· 58 citedOpen Access
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria
ACS Infectious Diseases·2016· 85 citedOpen Access
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
Journal of Medicinal Chemistry·2016· 89 citedOpen Access
Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
Journal of Medicinal Chemistry·2016· 18 citedOpen Access
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
Journal of Medicinal Chemistry·2016· 58 citedOpen Access
Plasmodium falciparumのジヒドロオロト酸デヒドロゲナーゼを標的とするテトラヒドロ‐2‐ナフチルおよび2‐インダニルトリアゾロピリミジンは強力で選択的な抗マラリア活性を示す
Journal of Medicinal Chemistry·2016
(deoxyribonucleotide/feedback-resistant enzyme/mouse T-lymphoma
2016
CCDC 1454120: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
A Novel Pyrazolopyridine with in Vivo Activity in <i>Plasmodium berghei</i>- and <i>Plasmodium falciparum</i><i>-</i>Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines
Journal of Medicinal Chemistry·2015· 36 citedOpen Access
Structure–Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines
Journal of Medicinal Chemistry·2015· 17 citedOpen Access
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate
Nature Communications·2015· 73 citedOpen Access
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Frequent Co-authors

Sergio Wittlin(17), Michael J. Witty(16), Susan A. Charman(14), Diego González Cabrera(13), Karen L. White(13), Leslie J. Street(13), Claire Le Manach(12), Yassir Younis(12), Íñigo Angulo‐Barturen(12), Tanya Paquet(11), Maria Santos Martínez(11), Jeremy N. Burrows(11), Kelly Chibale(11), Santiago Ferrer(10), Marı́a Belén Jiménez-Dı́az(10), Sandra Duffy(10), Vicky M. Avery(10), Francisco‐Javier Gamo(9), Didier Leroy(8), Aloysius T. Nchinda(8)