Yassir Younis

University of California, San Francisco — United States

Medicine · Health Sciences

14h-index955citations26works0.02yr avg
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Research Topics

Malaria Research and Control(8), Crystallization and Solubility Studies(8), HIV/AIDS drug development and treatment(7), X-ray Diffraction in Crystallography(7), Phenothiazines and Benzothiazines Synthesis and Activities(7)

Publications26 total

Synthesis, spectroscopic characterization, and DFT analysis of Cu(II) diamide complexes for optical chemical sensing applications
Chemistry of Inorganic Materials·2025Open Access
Small molecule inhibitors of a human recombination-associated ATPase, RAD54
2019Open Access
Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase
Science Translational Medicine·2017· 262 citedOpen Access
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle
Journal of Medicinal Chemistry·2016· 58 citedOpen Access
Synthesis and structure–activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2
European Journal of Medicinal Chemistry·2014· 53 cited
Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 2
Journal of Medicinal Chemistry·2014· 38 citedOpen Access
Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics
Malaria Journal·2014· 24 citedOpen Access
Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1
Journal of Medicinal Chemistry·2014· 48 citedOpen Access
2,4-Diaminothienopyrimidines as Orally Active Antimalarial Agents
Journal of Medicinal Chemistry·2014· 35 citedOpen Access
Alternative solid-state forms of a potent antimalarial aminopyridine: X-ray crystallographic, thermal and solubility aspects
CrystEngComm·2013· 7 cited
Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum
Malaria Journal·2013· 78 citedOpen Access
Structure–Activity-Relationship Studies around the 2-Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral in Vivo Activity
Journal of Medicinal Chemistry·2013· 49 citedOpen Access
Cell-Based Medicinal Chemistry Optimization of High Throughput Screening Hits for Orally Active Antimalarials. Part 2: Hits from SoftFocus Kinase and other Libraries
Journal of Medicinal Chemistry·2013· 16 citedOpen Access
CCDC 959480: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
CCDC 959476: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
CCDC 959477: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
CCDC 959478: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
CCDC 959475: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
CCDC 959479: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
CCDC 959474: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
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Frequent Co-authors

Kelly Chibale(18), Michael J. Witty(12), David Waterson(12), Diego González Cabrera(10), Sergio Wittlin(10), Leslie J. Street(10), Claire Le Manach(9), Karen L. White(8), Susan A. Charman(8), Dyanne L. Cruickshank(8), Nicholas M. Njuguna(8), Dennis S. B. Ongarora(8), Mino R. Caira(8), Tanya Paquet(7), Aloysius T. Nchinda(7), Frédèric Douelle(6), Sridevi Bashyam(5), Tzu‐Shean Feng(4), K. Mohammed Zabiulla(4), Dale Taylor(4)