Frédèric Douelle

University of Cape Town — South Africa

Chemistry · Physical Sciences

10h-index507citations15works0.02yr avg
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Research Topics

Synthesis and biological activity(6), Quinazolinone synthesis and applications(6), Phenothiazines and Benzothiazines Synthesis and Activities(5), Asymmetric Synthesis and Catalysis(3), Malaria Research and Control(3)

Publications15 total

Structure–Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines
Journal of Medicinal Chemistry·2015· 17 citedOpen Access
Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1
Journal of Medicinal Chemistry·2014· 48 citedOpen Access
2,4-Diaminothienopyrimidines as Orally Active Antimalarial Agents
Journal of Medicinal Chemistry·2014· 35 citedOpen Access
Structure–Activity-Relationship Studies around the 2-Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral in Vivo Activity
Journal of Medicinal Chemistry·2013· 49 citedOpen Access
Structure–Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2-Aminopyridines
Journal of Medicinal Chemistry·2012· 38 citedOpen Access
3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential
Journal of Medicinal Chemistry·2012· 134 citedOpen Access
Novel Orally Active Antimalarial Thiazoles
Journal of Medicinal Chemistry·2011· 81 citedOpen Access
Highly Diastereoselective Synthesis of vicinal Quaternary and Tertiary Stereocenters Using the Iodo‐aldol Cyclization.
ChemInform·2007Open Access
Highly Diastereoselective Synthesis of <i>vicinal</i> Quaternary and Tertiary Stereocenters Using the Iodo-aldol Cyclization
Organic Letters·2007· 35 cited
New Methods For Cyclopentannulation
ERA·2007Open Access
Reagent‐Free Nazarov Cyclizations.
ChemInform·2005
Reagent-free Nazarov cyclisations
Chemical Communications·2004· 28 cited
Preparation of Pyridinium and Diaminocarbonium Barbituric Acid Ylides
ScholarWorks - UNO (University of New Orleans)·2003Open Access
A New Facile Method for Preparation of Heterocyclic α‐Iminonitriles and α‐Oxoacetic from Heterocyclic Aldehydes, p‐Aminophenol, and Sodium Cyanide.
ChemInform·2002· 2 cited
A new facile method for preparation of heterocyclic α-iminonitriles and α-oxoacetic acid from heterocyclic aldehydes, p-aminophenol, and sodium cyanide
Tetrahedron Letters·2002· 40 cited

Frequent Co-authors

Diego González Cabrera(7), David Waterson(7), Michael J. Witty(7), Sergio Wittlin(7), Yassir Younis(6), Claire Le Manach(6), Aloysius T. Nchinda(6), Karen L. White(6), Susan A. Charman(6), Kelly Chibale(6), Leslie J. Street(5), Tzu‐Shean Feng(4), K. Mohammed Zabiulla(4), Sridevi Bashyam(4), Michael F. Greaney(4), Sandra Duffy(3), Jayan T. Joseph(3), Vicky M. Avery(3), Eileen Ryan(3), Tanya Paquet(3)