Darren R. March

University of Queensland — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.0kcitations23works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Chemical Synthesis and Analysis(11), Click Chemistry and Applications(9), HIV/AIDS drug development and treatment(7), RNA and protein synthesis mechanisms(5), HIV Research and Treatment(3)

Publications23 total

Potent Cyclic Antagonists of the Complement C5a Receptor on Human Polymorphonuclear Leukocytes. Relationships between Structures and Activity
Molecular Pharmacology·2004· 112 cited
Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207
Bioorganic & Medicinal Chemistry·2003· 16 cited
A Cyclic Metallopeptide Induces α Helicity in Short Peptide Fragments of Thermolysin
Angewandte Chemie International Edition·2003· 39 cited
A Cyclic Metallopeptide Induces α Helicity in Short Peptide Fragments of Thermolysin
Angewandte Chemie·2003· 16 cited
ChemInform Abstract: Multi‐Component Assembly of the Bicyclic Core Associated with the tRNA Synthetase Inhibitors SB‐203207 and SB‐203208. Application to the Synthesis of Biologically Active Analogues.
ChemInform·2002
CCDC 165269: Experimental Crystal Structure Determination
The Cambridge Structural Database·2002Open Access
Multi-component assembly of the bicyclic core associated with the tRNA synthetase inhibitors SB-203207 and SB-203208. Application to the synthesis of biologically active analogues.
Chemical Communications·2001· 17 cited
Control of peptide conformation by Palladium(II) coordination
Queensland's institutional digital repository (The University of Queensland)·2001
Analogues of SB-203207 as inhibitors of tRNA synthetases
Bioorganic & Medicinal Chemistry Letters·2000· 79 citedOpen Access
Synthesis, Stability, Antiviral Activity, and Protease-Bound Structures of Substrate-Mimicking Constrained Macrocyclic Inhibitors of HIV-1 Protease
Journal of Medicinal Chemistry·2000· 66 citedOpen Access
Conformational Selection of Inhibitors and Substrates by Proteolytic Enzymes:  Implications for Drug Design and Polypeptide Processing
Journal of Medicinal Chemistry·2000· 152 citedOpen Access
Molecular Recognition of Macrocyclic Peptidomimetic Inhibitors by HIV-1 Protease<sup>,</sup>
Biochemistry·1999· 46 citedOpen Access
A novel strategy for the design of potent peptidomimetic inhibitors of proteolytic enzymes: Application to HIV-1 protease.
Abstracts of papers - American Chemical Society·1997
Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease
Bioorganic & Medicinal Chemistry Letters·1996· 14 cited
ChemInform Abstract: Regioselective Structural and Functional Mimicry of Peptides. Design of Hydrolytically‐Stable Cyclic Peptidomimetic Inhibitors of HIV‐1 Protease.
ChemInform·1996
ChemInform Abstract: An Improved Synthesis of 2,2‐Disubstituted‐1,2‐dihydroquinolines and Their Conversion to 3‐Chloro‐2,2‐disubstituted‐tetrahydroquinolines.
ChemInform·1996
Substrate mimics as inhibitors of HIV-1 protease
1996
A Novel Bicyclic Enzyme Inhibitor as a Consensus Peptidomimetic for the Receptor-Bound Conformations of 12 Peptidic Inhibitors of HIV-1 Protease
Journal of the American Chemical Society·1996· 38 cited
Substrate-Based Cyclic Peptidomimetics of Phe-Ile-Val That Inhibit HIV-1 Protease Using a Novel Enzyme-Binding Mode
Journal of the American Chemical Society·1996· 76 cited
An improved synthesis of 2,2-disubstituted-1,2-dihydroquinolines and their conversion to 3-chloro-2,2-disubstituted-tetrahydroquinolines
Tetrahedron Letters·1995· 68 cited
page 1 of 2Next →

Frequent Co-authors

David P. Fairlie(15), Giovanni Abbenante(10), Robert C. Reid(8), Douglas A. Bergman(7), Martin G. Banwell(5), Curtis F. Crasto(5), Christopher J. Easton(5), Tomislav Karoli(5), Jennifer L. Martin(5), Michael R. Nairn(4), Peter J. O’Hanlon(4), Mark D. Oldham(4), Weimin Yue(4), Joel D. A. Tyndall(3), Martin J. Stoermer(3), Dianne Alewood(3), Paul F. Alewood(3), PHILIP A. HUNT(3), B. Garnham(3), R.J. Dancer(3)