Thomas C. Boone

University of Utah — United States

Immunology and Microbiology · Life Sciences

39h-index16.5kcitations80works5.02yr avg
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Research Topics

Immune Response and Inflammation(16), Monoclonal and Polyclonal Antibodies Research(12), Immune Cell Function and Interaction(10), Protein purification and stability(9), Neutropenia and Cancer Infections(8)

Publications80 total

Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation
Circulation Research·2025· 5 cited
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
PLoS ONE·2012· 163 citedOpen Access
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Cell·2010· 924 citedOpen Access
Light-induced aggregation of type I soluble tumor necrosis factor receptor
Journal of Pharmaceutical Sciences·2009· 35 citedOpen Access
Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation
2007· 6 cited
Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation
2006
Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching”
Nature Biotechnology·2002· 152 cited
Regulatory Effects of Novel Neurotrophin-1/B Cell-Stimulating Factor-3 (Cardiotrophin-Like Cytokine) on B Cell Function
The Journal of Immunology·2002· 54 cited
Characterization, Formulation, and Stability of Neupogen® (Filgrastim), a Recombinant Human Granulocyte-Colony Stimulating Factor
Pharmaceutical biotechnology·2002· 92 cited
Asn to Lys mutations at three sites which are N-glycosylated in the mammalian protein decrease the aggregation of Escherichia coli-derived erythropoietin
Protein Engineering Design and Selection·2001· 46 citedOpen Access
Protection against the mortality associated with disease models mediated by TNF and IFN-gamma in mice lacking IFN regulatory factor-1.
PubMed·1999· 71 cited
Protection Against the Mortality Associated with Disease Models Mediated by TNF and IFN-γ in Mice Lacking IFN Regulatory Factor-1
The Journal of Immunology·1999· 65 citedOpen Access
Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family
Proceedings of the National Academy of Sciences·1999· 246 citedOpen Access
A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3
Journal of Bone and Mineral Research·1999· 186 citedOpen Access
Chemical Modification and Site-Directed Mutagenesis of Methionine Residues in Recombinant Human Granulocyte Colony-Stimulating Factor: Effect on Stability and Biological Activity
Archives of Biochemistry and Biophysics·1999· 72 cited
Biopharmaceutical Drug Development: A Case History
1999· 2 cited
Targeted Steam Injection Using Horizontal Wells with Limited Entry Perforations
1998· 3 cited
GFRα-2 and GFRα-3 Are Two New Receptors for Ligands of the GDNF Family
Journal of Biological Chemistry·1997· 229 citedOpen Access
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
Cell·1997· 5.1k citedOpen Access
The Majority of Stem Cell Factor Exists as Monomer under Physiological Conditions
Journal of Biological Chemistry·1997· 75 citedOpen Access
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Frequent Co-authors

L M Souza(13), Keith Langley(8), Hsieng S. Lu(7), Linda O. Narhi(7), Giorgio Senaldi(4), Jane Guo(4), Jette Wypych(4), Christi L. Clogston(4), W. Scott Simonet(3), Grant Shimamoto(3), Krisztina M. Zsebo(3), Vicki R. Chazin(3), Karl Welte(3), Christine L. Shaklee(3), Tsutomu Arakawa(3), Elizabeth A. Mendiaz(3), Marcus E. Kehrli(3), Colin R. Dunstan(2), Ming‐Shi Chang(2), Gwyneth Van(2)