Gareth Waldron

Neuroscience · Life Sciences

16h-index1.9kcitations34works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(9), Cardiac electrophysiology and arrhythmias(9), Ion channel regulation and function(9), Nitric Oxide and Endothelin Effects(6), Receptor Mechanisms and Signaling(5)

Publications34 total

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain
Journal of Medicinal Chemistry·2018· 35 citedOpen Access
Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors
Journal of Medicinal Chemistry·2018· 52 citedOpen Access
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain
Journal of Medicinal Chemistry·2016· 80 citedOpen Access
effect of pollen sensitization and PKC activation current of dog bronchial myocytes: + Delayed rectifier K
2016
Recommendations for Safety Pharmacology Evaluations of Oligonucleotide-Based Therapeutics
Nucleic Acid Therapeutics·2014· 41 cited
Use of the beam walking and drug discrimination models for determining intrinsic efficacy and selectivity of subtype selective GABA-A ligands in rodents
Journal of Pharmacological and Toxicological Methods·2013
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
Nature Reviews Drug Discovery·2012· 729 cited
Evaluation of contextual renewal as a nonclinical model for cognitive deficits
Journal of Pharmacological and Toxicological Methods·2011
Rational design of an in vitro safety profiling panel to reduce undesired secondary pharmacology of drug candidates
Journal of Pharmacological and Toxicological Methods·2011· 1 cited
Use of Zebrafish in safety pharmacology
Journal of Pharmacological and Toxicological Methods·2010
Characterization of three seizure models for use in safety pharmacology
Journal of Pharmacological and Toxicological Methods·2010
An investigation of non-selective and selective GABAA ligands using the beam walking assay in rats and mice
Journal of Pharmacological and Toxicological Methods·2010
In vitro rat hippocampal slice model for pro-convulsion liability assessment
Journal of Pharmacological and Toxicological Methods·2010
CNS safety pharmacology (including drug dependency)
Toxicology Letters·2009
Multiple mechanisms of QTC shortening
Journal of Pharmacological and Toxicological Methods·2008· 3 cited
Potential value of zebrafish (Danio rerio) larvae as a front-loaded in vivo screen to assess safety pharmacology endpoin
Journal of Pharmacological and Toxicological Methods·2008
Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery
Journal of Pharmacological and Toxicological Methods·2008· 187 cited
Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?
Journal of Pharmacological and Toxicological Methods·2008· 69 cited
Prediction Of Ophthalmic Effects In Man By Screening Drugs For The Optokinetic And Optomotor Responses In Zebrafish
Investigative Ophthalmology & Visual Science·2006· 2 cited
Assay Technologies: Techniques Available for Quantifying Drug–Channel Interactions
Methods and principles in medicinal chemistry·2006· 6 cited
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Frequent Co-authors

Chris R. Triggle(5), William C. Cole(5), Richard J. Newman(5), Paul Butler(4), Karen Tse(4), C J Garland(3), Sharan K. Bagal(3), James Bilsland(3), Peter J. Bungay(3), Kiyoyuki Omoto(3), Matthew J. Winter(3), Mark Holbrook(3), Joanne Bowes(2), Andrew J. Brown(2), Jacques Hamon(2), Wolfgang Jarolimek(2), Arun Sridhar(2), Steven Whitebread(2), Frances M. Richards(2), G.M. Kimber(2)