James C. Tarr

Vanderbilt University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.1kcitations35works3.22yr avg
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Research Topics

Receptor Mechanisms and Signaling(15), Neuroscience and Neuropharmacology Research(10), Chemical Synthesis and Analysis(6), Pharmacological Receptor Mechanisms and Effects(6), Nicotinic Acetylcholine Receptors Study(5)

Publications35 total

Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19
EBioMedicine·2025Open Access
Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model
Journal of Medicinal Chemistry·2025Open Access
Discovery of Pre-Clinical Candidate <b>VU6008055</b>/<b>AF98943</b>: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy
ACS Chemical Neuroscience·2025· 2 citedOpen Access
Common and rare variant analyses reveal novel genetic factors underlying Idiopathic Pulmonary Fibrosis and shared aetiology with COVID-19
2024Open Access
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent <i>In Vivo</i> Activities in Mouse Models of Hematological and Solid Tumors
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
Enantioselective Metallophosphite-Catalyzed C-Acylation of Nitrones
Figshare·2020Open Access
CCDC 2023739: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Journal of Medicinal Chemistry·2019· 64 citedOpen Access
Fragment-based screening of programmed death ligand 1 (PD-L1)
Bioorganic & Medicinal Chemistry Letters·2019· 55 citedOpen Access
Corrigendum to “Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides” [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]
Bioorganic & Medicinal Chemistry Letters·2018· 1 cited
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design
Journal of Medicinal Chemistry·2018· 64 citedOpen Access
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides
Bioorganic & Medicinal Chemistry Letters·2017· 22 citedOpen Access
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
Bioorganic & Medicinal Chemistry Letters·2017· 26 citedOpen Access
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Bioorganic & Medicinal Chemistry Letters·2016· 40 citedOpen Access
Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors
FEBS Letters·2016· 61 citedOpen Access
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition
Bioorganic & Medicinal Chemistry Letters·2016· 12 citedOpen Access
Abstract 3727: Small molecule Mcl-1 inhibitors induce apoptosis and death in multiple cancer subtypes <i>in vitro</i>
Cancer Research·2016· 1 cited
Abstract 3551: Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines
Cancer Research·2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core
Bioorganic & Medicinal Chemistry Letters·2016· 23 citedOpen Access
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
Journal of Medicinal Chemistry·2016· 143 citedOpen Access
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Frequent Co-authors

Craig W. Lindsley(19), P. Jeffrey Conn(17), Thomas M. Bridges(16), Colleen M. Niswender(15), Michael R. Wood(14), Bruce J. Melancon(10), Taekyu Lee(10), Edward T. Olejniczak(10), Stephen W. Fesik(10), J. Scott Daniels(9), Allison L. Arnold(9), John Sensintaffar(9), Hyekyung P. Cho(9), Carrie K. Jones(8), Bin Zhao(8), Alice L. Rodriguez(8), Meredith J. Noetzel(7), Atin Lamsal(7), Mark E. Duggan(7), Michael W. Wood(7)