Analisa D. Thompson

Vanderbilt University — United States

Neuroscience · Life Sciences

15h-index1.3kcitations30works1.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(19), Receptor Mechanisms and Signaling(11), Ion channel regulation and function(3), Neuroscience and Neural Engineering(3), Molecular Sensors and Ion Detection(2)

Publications30 total

Discovery of a Novel sp<sup>3</sup>-Rich M<sub>1</sub> Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping
ACS Medicinal Chemistry Letters·2025· 1 citedOpen Access
Development of Potent and Selective Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 2 for the Potential Treatment of Alzheimer’s Disease
Alzheimer s & Dementia·2023· 3 citedOpen Access
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy
Bioorganic & Medicinal Chemistry Letters·2016· 3 citedOpen Access
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy
Journal of Pharmacology and Experimental Therapeutics·2015· 35 citedOpen Access
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
Journal of Medicinal Chemistry·2015· 67 citedOpen Access
Partial mGlu5 Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects
Neuropsychopharmacology·2015· 43 citedOpen Access
Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents
Neuron·2015· 128 citedOpen Access
Selective Antagonism of mGlu5 Alters Sleep‐wake and Spectral EEG and Ameliorates Behavioral Abnormalities in a Rodent Model of Traumatic Stress
The FASEB Journal·2015· 1 cited
Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
Neuropharmacology·2015· 50 citedOpen Access
Discovery of (<i>S</i>)-2-Cyclopentyl-<i>N</i>-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1<i>H</i>-pyrrido[3,4-<i>b</i>]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)
Journal of Medicinal Chemistry·2014· 44 citedOpen Access
Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100
Neuropsychopharmacology·2014· 119 citedOpen Access
Figure 2, ML218 selectively blocks T-type Ca2+ currents without affecting voltage-gated Na+ and K+ currents in DRG neurons
2013
Figure 1, Dose-response curves for ML218
2013
Table 1, Stability in Phosphate Buffer
2013
Scaffold Hopping Affords a Highly Selective in vitro and in vivo T-Type Calcium Inhibitor Probe Free From IP Issues
2013· 3 cited
Figure 3, ML218 reverses haloperidol-induced catalepsy in a dose-dependent manner upon oral dosing
2013
Table 2, Calculated Property Comparison with MDDR Compounds
2013
Figure 2, Human (A) and rat (B) mGlu4 PAM CRC’s for ML292
2013
Discovery of a novel metabotropic glutamate receptor 4 (mGlu4) positive allosteric modulator (PAM) extended probe
2013
Table 1, Stability of ML292
2013
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Frequent Co-authors

Carrie K. Jones(28), Craig W. Lindsley(28), P. Jeffrey Conn(19), Colleen M. Niswender(17), J. Scott Daniels(13), Ryan D. Morrison(12), Darren W. Engers(10), Corey R. Hopkins(10), Thomas M. Bridges(9), C. David Weaver(9), Michael Bubser(9), Anna L. Blobaum(9), Julie L. Engers(8), Eric S. Dawson(7), Owen B. McManus(7), John T. Brogan(6), L. Michelle Lewis(6), Zixiu Xiang(5), M. Schulte(5), Debbie Mi(5)