Gerrit‐Jan Koomen

University of Amsterdam — Netherlands

Chemistry · Physical Sciences

23h-index2.6kcitations85works0.02yr avg
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Research Topics

Synthesis and Biological Evaluation(20), Adenosine and Purinergic Signaling(13), Cancer therapeutics and mechanisms(12), Carbohydrate Chemistry and Synthesis(7), Chemical Synthesis and Analysis(7)

Publications85 total

Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy
Antimicrobial Agents and Chemotherapy·2015· 21 citedOpen Access
Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors
Journal of Medicinal Chemistry·2014· 50 citedOpen Access
Synthesis of Marine-Derived 3-Alkylpyridinium Alkaloids with Potent Antiprotozoal Activity
ACS Medicinal Chemistry Letters·2011· 8 cited
Probing FtsZ and Tubulin with C8-Substituted GTP Analogs Reveals Differences in Their Nucleotide Binding Sites
Chemistry & Biology·2008· 80 citedOpen Access
2,N <sup>6</sup> -Disubstituted Adenosine Analogs with Antitrypanosomal and Antimalarial Activities
Antimicrobial Agents and Chemotherapy·2007· 46 citedOpen Access
ABCG2 (Breast Cancer Resistance Protein/Mitoxantrone Resistance-Associated Protein) ATPase Assay: A Useful Tool to Detect Drug-Transporter Interactions
Drug Metabolism and Disposition·2007· 71 cited
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5′-carboxamidoadenosine analogues
Bioorganic & Medicinal Chemistry·2005· 22 cited
GTP Analogue Inhibits Polymerization and GTPase Activity of the Bacterial Protein FtsZ without Affecting Its Eukaryotic Homologue Tubulin
Biochemistry·2005· 77 cited
The Mechanism of Selective Purine C-Nitration Revealed:  NMR Studies Demonstrate Formation and Radical Rearrangement of an N7-Nitramine Intermediate
Journal of the American Chemical Society·2005· 19 cited
Function-dependent Conformational Changes of the ABCG2 Multidrug Transporter Modify Its Interaction with a Monoclonal Antibody on the Cell Surface
Journal of Biological Chemistry·2004· 92 citedOpen Access
Synthesis and Antitumor Activity of Methyltriazene Prodrugs Simultaneously Releasing DNA-Methylating Agents and the Antiresistance Drug <i>O</i><sup>6</sup>-Benzylguanine
Journal of Medicinal Chemistry·2004· 61 cited
<i>N</i><sup>6</sup>-Cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a Very Selective Agonist with High Affinity for the Human Adenosine A<sub>1</sub> Receptor
Journal of Medicinal Chemistry·2003· 44 citedOpen Access
A New Synthesis of Temozolomide.
ChemInform·2003
A new synthesis of temozolomide
Journal of the Chemical Society Perkin Transactions 1·2002· 15 cited
Solid phase synthesis of C2,N6-disubstituted adenosine analogues
Journal of the Chemical Society Perkin Transactions 1·2002· 16 cited
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.
PubMed·2002· 687 cited
ChemInform Abstract: Enantiopure Tetrahydroisoquinolines via N‐Sulfinyl Pictet—Spengler Reactions.
ChemInform·2002
ChemInform Abstract: Synthesis and Properties of 2‐Nitrosoadenosine.
ChemInform·2002
Enantiopure tetrahydroisoquinolines via N -sulfinyl Pictet–Spengler reactions
Tetrahedron Letters·2001· 49 cited
ChemInform Abstract: Synthesis of Xestomanzamines A and B.
ChemInform·2001
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Frequent Co-authors

Martin J. Wanner(31), Upendra K. Pandit(11), Boris Rodenko(5), Arnold van Loevezijn(4), Christiaan Gremmen(4), Brigitte E. A. Burm(4), Alida M. van der Burg(3), Victorine A. Pinas(3), Reto Brun(3), Paymaneh Y.F Deghati(3), A. LANGENDOEN(3), John Allen(2), Alfred H. Schinkel(2), Herman S. Overkleeft(2), Anneke Strijland(2), Johannes M. F. G. Aerts(2), Tilman Läppchen(2), Aloysius F. Hartog(2), Tanneke den Blaauwen(2), Melle Koch(2)