R. William Hipkin

Bristol-Myers Squibb (United States) — United States

Medicine · Health Sciences

32h-index3.8kcitations54works46.02yr avg
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Research Topics

Chemokine receptors and signaling(16), Cannabis and Cannabinoid Research(12), Receptor Mechanisms and Signaling(7), Neuroscience and Neuropharmacology Research(6), Hypothalamic control of reproductive hormones(6)

Publications54 total

First-Line Nivolumab and Relatlimab Plus Chemotherapy for Gastric or Gastroesophageal Junction Adenocarcinoma: The Phase II RELATIVITY-060 Study
Journal of Clinical Oncology·2024· 46 citedOpen Access
Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands
Bioorganic & Medicinal Chemistry Letters·2010· 20 citedOpen Access
Opioid Receptor Antagonists for Gastrointestinal Dysfunction
Annual reports in medicinal chemistry·2010· 2 cited
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 11 citedOpen Access
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region
Bioorganic & Medicinal Chemistry Letters·2009· 8 citedOpen Access
Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 14 citedOpen Access
3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 13 citedOpen Access
CXCR2 antagonists for the treatment of pulmonary disease
Pharmacology & Therapeutics·2008· 210 cited
Synthesis and structure–activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 17 citedOpen Access
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 23 citedOpen Access
Biology and therapeutic potential of cannabinoid CB<sub>2</sub>receptor inverse agonists
British Journal of Pharmacology·2007· 120 citedOpen Access
Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB<sub>2</sub>) in rodents and primates
British Journal of Pharmacology·2007· 19 citedOpen Access
Pharmacological Characterization of Sch527123, a Potent Allosteric CXCR1/CXCR2 Antagonist
Journal of Pharmacology and Experimental Therapeutics·2007· 127 cited
A Novel, Orally Active CXCR1/2 Receptor Antagonist, Sch527123, Inhibits Neutrophil Recruitment, Mucus Production, and Goblet Cell Hyperplasia in Animal Models of Pulmonary Inflammation
Journal of Pharmacology and Experimental Therapeutics·2007· 140 cited
Cannabinoid CB<sub>2</sub>-Selective Inverse Agonist Protects Against Antigen-Induced Bone Loss
Immunopharmacology and Immunotoxicology·2007· 24 cited
Murine CXCR1 Is a Functional Receptor for GCP-2/CXCL6 and Interleukin-8/CXCL8
Journal of Biological Chemistry·2006· 204 citedOpen Access
Discovery of 2-Hydroxy-<i>N</i>,<i>N</i>-dimethyl-3-{2-[[(<i>R</i>)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist
Journal of Medicinal Chemistry·2006· 113 citedOpen Access
Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel Radioligand, [35S]Sch225336
Journal of Biological Chemistry·2006· 30 citedOpen Access
A Novel Cannabinoid Peripheral Cannabinoid Receptor-Selective Inverse Agonist Blocks Leukocyte Recruitment in Vivo
Journal of Pharmacology and Experimental Therapeutics·2006· 140 cited
Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel
2006
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Frequent Co-authors

Waldemar Gonsiorek(22), Jay S. Fine(17), Daniel Lundell(15), Xuedong Fan(13), Charles A. Lunn(11), Joseph A. Kozlowski(9), Gregory Deno(8), Agnes Schönbrunn(8), Brian J. Lavey(8), Mario Ascoli(8), James Fossetta(7), Satwant K. Narula(6), Diane Rindgen(6), Jianhua Chao(6), Paul J. Zavodny(6), Younong Yu(6), Purakkattle Biju(6), Arthur G. Taveras(6), Michael P. Dwyer(5), James Jakway(4)