Xuedong Fan

Jiangnan University — China

Medicine · Health Sciences

15h-index1.7kcitations22works0.02yr avg
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Research Topics

Chemokine receptors and signaling(11), Immune Response and Inflammation(4), Immunotherapy and Immune Responses(4), Synthesis and biological activity(3), Multicomponent Synthesis of Heterocycles(3)

Publications22 total

Preparation of a multifunctional fibroin-based biomaterial via laccase-assisted grafting of chitooligosaccharide
International Journal of Biological Macromolecules·2018· 49 cited
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region
Bioorganic & Medicinal Chemistry Letters·2009· 8 citedOpen Access
Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 14 citedOpen Access
3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 13 citedOpen Access
Synthesis and structure–activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 17 citedOpen Access
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 23 citedOpen Access
Pharmacological Characterization of Sch527123, a Potent Allosteric CXCR1/CXCR2 Antagonist
Journal of Pharmacology and Experimental Therapeutics·2007· 127 cited
A Novel, Orally Active CXCR1/2 Receptor Antagonist, Sch527123, Inhibits Neutrophil Recruitment, Mucus Production, and Goblet Cell Hyperplasia in Animal Models of Pulmonary Inflammation
Journal of Pharmacology and Experimental Therapeutics·2007· 140 cited
C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 43 citedOpen Access
Murine CXCR1 Is a Functional Receptor for GCP-2/CXCL6 and Interleukin-8/CXCL8
Journal of Biological Chemistry·2006· 204 citedOpen Access
Discovery of 2-Hydroxy-<i>N</i>,<i>N</i>-dimethyl-3-{2-[[(<i>R</i>)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist
Journal of Medicinal Chemistry·2006· 113 citedOpen Access
A Novel Cannabinoid Peripheral Cannabinoid Receptor-Selective Inverse Agonist Blocks Leukocyte Recruitment in Vivo
Journal of Pharmacology and Experimental Therapeutics·2006· 140 cited
Pharmacological characterization of human S1P<sub>4</sub> using a novel radioligand, [4,5‐<sup>3</sup>H]‐dihydrosphingosine‐1‐phosphate
British Journal of Pharmacology·2004· 13 citedOpen Access
Cloning and Pharmacological Characterization of CXCR1 and CXCR2 from Macaca fascicularis
Journal of Pharmacology and Experimental Therapeutics·2004· 16 cited
Inhibition of fucosyltransferase VII by gallic acid and its derivatives
Archives of Biochemistry and Biophysics·2004· 29 citedOpen Access
Pharmacological Analysis of Calcium Responses Mediated by the Human A3 Adenosine Receptor in Monocyte-Derived Dendritic Cells and Recombinant Cells
Molecular Pharmacology·2003· 63 cited
P2Y13: Identification and Characterization of a Novel Gαi-Coupled ADP Receptor from Human and Mouse
Journal of Pharmacology and Experimental Therapeutics·2002· 160 cited
Endocannabinoid 2-Arachidonyl Glycerol Is a Full Agonist through Human Type 2 Cannabinoid Receptor: Antagonism by Anandamide
Molecular Pharmacology·2000· 369 cited
Development of a CD28 Receptor Binding-Based Screen and Identification of a Biologically Active Inhibitor
Analytical Biochemistry·1998· 13 cited
Purification of ADAM 10 from bovine spleen as a TNFα convertase
FEBS Letters·1997· 131 citedOpen Access
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Frequent Co-authors

Daniel Lundell(14), R. William Hipkin(13), Waldemar Gonsiorek(10), Jay S. Fine(10), Diane Rindgen(7), James Fossetta(7), Jianhua Chao(7), Younong Yu(7), Purakkattle Biju(7), Arthur G. Taveras(7), Gregory Deno(6), Michael P. Dwyer(6), Charles A. Lunn(5), Satwant K. Narula(5), James Jakway(5), Jianping Chao(4), Cynthia Aki(4), J. Robert Merritt(4), Richard Bond(3), Paul J. Zavodny(3)