Cynthia Aki

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index209citations10works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(5), Chemokine receptors and signaling(4), Asymmetric Synthesis and Catalysis(2), Multicomponent Synthesis of Heterocycles(2), Chemical Synthesis and Reactions(2)

Publications10 total

Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres
Tetrahedron Letters·2009· 12 cited
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region
Bioorganic & Medicinal Chemistry Letters·2009· 8 citedOpen Access
Synthesis and structure–activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 17 citedOpen Access
A Two‐Step Procedure for the Preparation of Mono‐Protected Bis‐N‐heterocyclic Alkyl Ether Systems.
ChemInform·2007
C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 43 citedOpen Access
Corrigendum to “A two-step procedure for the preparation of mono-protected bis-N-heterocyclic alkyl ether systems”
Tetrahedron Letters·2007· 1 cited
A two-step procedure for the preparation of mono-protected bis-N-heterocyclic alkyl ether systems
Tetrahedron Letters·2006· 8 cited
Discovery of 2-Hydroxy-<i>N</i>,<i>N</i>-dimethyl-3-{2-[[(<i>R</i>)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist
Journal of Medicinal Chemistry·2006· 113 citedOpen Access
Exploring the Role of Bromine at C(10) of (+)-4-[2-[4-(8-Chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(<i>R</i>)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336):  The Discovery of Indolocycloheptapyridine Inhibitors of Farnesyl Protein Transferase
Journal of Medicinal Chemistry·2002· 7 citedOpen Access
Inhibiting Fornesyl Protein Transferase with Sch-66336: Potentially a Selective, Noncytotoxic Therapy for Human Cancer
ACS symposium series·2001

Frequent Co-authors

Jianhua Chao(8), Arthur G. Taveras(7), Jianping Chao(5), Michael P. Dwyer(4), Younong Yu(4), Purakkattle Biju(4), Diane Rindgen(4), Xuedong Fan(4), Jay S. Fine(4), Daniel Lundell(4), James Jakway(3), R. William Hipkin(3), Waldemar Gonsiorek(3), J. Robert Merritt(3), Mariam Israiel(3), Viyyoor Girijavallabhan(2), Richard Bond(2), Rosemary Mayer-Ezel(2), James Fossetta(2), Hong Bian(2)