M.Th.M. Tulp

Wageningen University & Research — Netherlands

Neuroscience · Life Sciences

24h-index1.9kcitations77works0.02yr avg
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Research Topics

Neurotransmitter Receptor Influence on Behavior(21), Receptor Mechanisms and Signaling(16), Toxic Organic Pollutants Impact(10), Analytical Chemistry and Chromatography(10), Synthesis and Biological Evaluation(10)

Publications77 total

Commentary on the Novel Sensing Technologies and Chemometrics Course
NIR news·2025Open Access
Synthesis, Structure−Activity Relationships, and Biological Properties of 1-Heteroaryl-4-[ω-(1<i>H</i>-indol-3-yl)alkyl]piperazines, Novel Potential Antipsychotics Combining Potent Dopamine D<sub>2</sub> Receptor Antagonism with Potent Serotonin Reuptake Inhibition
Journal of Medicinal Chemistry·2005· 58 citedOpen Access
Rediscovery of known natural compounds: nuisance or goldmine?
Trends in Pharmacological Sciences·2005· 16 cited
SLV310, a Novel, Potential Antipsychotic, Combining Potent Dopamine D<sub>2</sub> Receptor Antagonism with Serotonin Reuptake Inhibition.
ChemInform·2003
DU 127090: A novel partial dopamine agonist with antipsychotic activity high potency but low efficacy at dopamine D2 receptors in vitro
Schizophrenia Research·2003· 4 cited
SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition
Bioorganic & Medicinal Chemistry Letters·2003· 27 citedOpen Access
ChemInform Abstract: New 1‐Aryl‐4‐(biarylmethylene)piperazines as Potential Atypical Antipsychotics Sharing Dopamine D<sub>2</sub>‐Receptor and Serotonin 5‐HT<sub>1A</sub>‐Receptor Affinities.
ChemInform·2001
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities
Bioorganic & Medicinal Chemistry Letters·2001· 40 citedOpen Access
DU 127090: a highly potent, atypical dopamine receptor ligand — high potency but low efficacy at dopamine D2 receptors in vitro
European Neuropsychopharmacology·2000· 12 cited
C5-Substituted Derivatives of 5-OMe-BPAT: Synthesis and Interactions with Dopamine D2 and Serotonin 5-HT1A Receptors
Bioorganic & Medicinal Chemistry·1999· 5 cited
The use of Receptor Binding, a Very Specific, High Capacity Screening Method, in the Identification of Biologically Active Components from Natural Sources
1999· 2 cited
Synthesis and structure–Activity data of some new epibatidine analogues
Bioorganic & Medicinal Chemistry·1998· 33 cited
5-HT<sub>1A</sub>- versus D<sub>2</sub>-Receptor Selectivity of Flesinoxan and Analogous<i>N</i> <sup>4</sup>-Substituted<i>N</i> <sup>1</sup>-Arylpiperazines
Journal of Medicinal Chemistry·1997· 61 citedOpen Access
Ligand binding assays
Pharmacochemistry library·1997
ChemInform Abstract: A Series of N4‐Imidoethyl Derivatives of 1‐(2,3‐Dihydro‐1,4‐ benzodioxin‐5‐yl)piperazine as 5‐HT1A Receptor Ligands: Synthesis and Structure‐Affinity Relationships.
ChemInform·1996· 1 cited
A Series of N4-Imidoethyl Derivatives of 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine as 5-HT1A Receptor Ligands: Synthesis and Structure-Affinity Relationships
Journal of Medicinal Chemistry·1995· 19 citedOpen Access
Evaluation of the receptor selectivity of the H<sub>3</sub> receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT<sub>3</sub> receptor revealed
British Journal of Pharmacology·1995· 67 citedOpen Access
N4-Unsubstituted N1-Arylpiperazines as High-Affinity 5-HT1A Receptor Ligands
Journal of Medicinal Chemistry·1995· 35 citedOpen Access
Structure-Affinity Relationship Studies on 5-HT1A receptor Ligands. 2. Heterobicyclic Phenylpiperazines with N4-Aralkyl Substituents
Journal of Medicinal Chemistry·1994· 48 citedOpen Access
Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan
European Journal of Pharmacology·1994· 18 cited
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Frequent Co-authors

O. Hutzinger(14), Chris G. Kruse(10), I. van Wijngaarden(9), Berend Olivier(7), J. Mos(7), J. Schipper(6), W. Soudijn(4), J.A.M. van der Heyden(4), Rolf van Hes(3), Göran Sundström(3), Wilma Kuipers(3), M.B. Hesselink(3), Bart J. van Steen(3), Jan Van der Heyden(3), G. van der Poel(3), Andreas Fuchs(3), Michael Ruhland(3), Wout Wouters(2), Piet J. Standaar(2), Frans Mol(2)