Chris G. Kruse

Kinderkrebs-Zentrum Hamburg — Germany

Neuroscience · Life Sciences

45h-index5.9kcitations190works59.02yr avg
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Research Topics

Neurotransmitter Receptor Influence on Behavior(43), Neuroscience and Neuropharmacology Research(29), Asymmetric Synthesis and Catalysis(28), Cannabis and Cannabinoid Research(26), Receptor Mechanisms and Signaling(23)

Publications187 total

Homozygous <i>DBX1</i> Nonsense Variant in a Case of Atypical Congenital Central Hypoventilation
Neurology Genetics·2025· 1 citedOpen Access
Identification of Novel pan-KRAS Inhibitors via Structure-Based Drug Design, Scaffold Hopping, and Biological Evaluation
ACS Medicinal Chemistry Letters·2025· 2 citedOpen Access
Discovery of Bis-imidazolecarboxamide Derivatives as Novel, Potent, and Selective TNIK Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
Journal of Medicinal Chemistry·2024· 11 cited
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Nature Biotechnology·2024· 222 citedOpen Access
PF714 PATIENT PERCEPTIONS ON SPLENECTOMY OUTCOMES: RESULTS FROM THE ITP WORLD IMPACT SURVEY (I‐WISH)
HemaSphere·2019· 3 citedOpen Access
Dynamics of large-amplitude mountain waves in the mesosphere due to weak orographic forcing during DEEPWAVE research flight RF22
EGUGA·2018
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P5 receptor agonist chemotype
Bioorganic & Medicinal Chemistry Letters·2017· 1 cited
Cannabinoid antagonist SLV326 induces convulsive seizures and changes in the interictal EEG in rats
PLoS ONE·2017· 8 citedOpen Access
The selective 5-HT 6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment
Neurobiology of Learning and Memory·2016· 22 cited
Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket
Bioorganic & Medicinal Chemistry Letters·2016· 3 citedOpen Access
CCDC 1507380: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Do cannabinoid antagonists affect cognition? SLV326 induces changes in theta and gamma bands in active rats
Data Archiving and Networked Services (DANS)·2016Open Access
5-HT&lt;sub&gt;6&lt;/sub&gt; Receptor Antagonists: Potential Efficacy for the Treatment of Cognitive Impairment in Schizophrenia
Current Pharmaceutical Design·2015· 66 cited
Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons
Journal of the American Chemical Society·2015· 63 cited
Allosteric Inhibition of the Neuropeptidase Neurolysin
Journal of Biological Chemistry·2014· 24 citedOpen Access
Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex
Pflügers Archiv - European Journal of Physiology·2014· 37 cited
Endocannabinoids produced upon action potential firing evoke a Cl− current via type-2 cannabinoid receptors in the medial prefrontal cortex
Pflügers Archiv - European Journal of Physiology·2014· 16 cited
Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds
Tetrahedron·2013· 17 cited
A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats
Behavioural Brain Research·2012· 37 cited
Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors
Proceedings of the National Academy of Sciences·2012· 180 citedOpen Access
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Frequent Co-authors

Jos H.M. Lange(11), Hein K. A. C. Coolen(5), Herman H. van Stuivenberg(5), Arnoud H. J. Herremans(5), Andrew C. McCreary(5), Johannes Brussee(5), A. VAN DER GEN(5), Natasja de Bruin(5), Hiskias G. Keizer(4), Henri C. Wals(4), Bob Stork(4), Peter C. Verveer(4), Arnold P. den Hartog(4), Jennifer Venhorst(4), Wytse J. Wadman(4), Taco R. Werkman(4), Jan H. van Maarseveen(4), Jan M. van Ree(4), Martina A.W. van der Neut(4), M.Th.M. Tulp(4)