Philberta Leung

Oregon National Primate Research Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

2h-index23citations12works0.02yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(9), Nanoplatforms for cancer theranostics(4), Cancer Research and Treatments(4), Glioma Diagnosis and Treatment(2), Immune cells in cancer(2)

Publications12 total

Age-dependent cognitive impairment, hydrocephalus and leukocyte infiltration in transgenic mice with endothelial expression of human EPHX2
npj Aging·2022· 13 citedOpen Access
Systemic polidocanol from intravenous or pressurized intrauterine administration produces reversible cardiovascular toxicity
JVS Vascular Science·2022Open Access
TMIC-15. OMX IS A TUMOR MICROENVIRONMENT MODIFIER THAT RESTORES ANTI-TUMOR IMMUNITY AND IMPROVES ANTI-TUMOR EFFICACY BY REDUCING TUMOR HYPOXIA IN INTRACRANIAL GLIOBLASTOMA MOUSE MODEL
Neuro-Oncology·2018Open Access
Abstract 4726A: The oxygen carrier omx restores antitumor immunity and cures tumors as a single agent or in combination with checkpoint inhibitors in an intracranial glioblastoma mouse model
Cancer Research·2018· 2 cited
Abstract 4686: Omx a hypoxia modulator reverses the immunosuppressive glioblastoma microenvironment by stimulating T cell infiltration and activation that results in increased number of long-term survivors
Cancer Research·2017· 5 cited
IMST-52. OMX, AN IND-STAGE BROAD-ACTING OXYGEN CARRIER, IMMUNOSENSITIZES THE TUMOR MICROENVIRONMENT AND PROMOTES EFFECTOR T CELL RESPONSES IN THE GL261 INTRACRANIAL SYNGENEIC GLIOBLASTOMA MODEL
Neuro-Oncology·2016Open Access
Abstract B029: OMX: An oxygen carrier biotherapeutic that ameliorates the hypoxic tumor microenvironment and promotes anticancer T cell activity
Cancer Immunology Research·2016
Abstract 2790: Sensitizing the hypoxic tumor microenvironment with OMX, a breakthrough oxygen delivery protein: From protein engineering to clinical trial
Cancer Research·2016
Abstract 67: Novel and Safe Oxygen Carrier Prevents Brain Damage After Focal Ischemia and Improves Functional Outcomes
Stroke·2016· 1 cited
NIMG-45REAL-TIME PET IMAGING DEMONSTRATES TUMOR ACCUMULATION AND OXYGENATION BY OMX-4.80P, AN OXYGEN CARRIER ENGINEERED FOR THE TREATMENT OF GLIOBLASTOMA
Neuro-Oncology·2015Open Access
ATPS-49RESULTS OF A PHASE 0 CLINICAL TRIAL IN CANINE BRAIN CANCER EVALUATING SAFETY AND ACTIVITY OF OMX-4.80P, A PROTEIN OXYGEN CARRIER IND CANDIDATE FOR TREATMENT OF GLIOBLASTOMA
Neuro-Oncology·2015Open Access
Abstract 3003: OMX-4.80P, a novel H-NOX oxygen carrier that oxygenates hypoxic tumors in multiple tumor models and canine cancer patients, downregulates HIF-1 pathway and increases response to radiation therapy leading to cures
Cancer Research·2015· 2 cited

Frequent Co-authors

Natacha Le Moan(10), Stephen P. Cary(10), Ana Krtolica(10), Sarah Ng(8), Tina Davis(8), Jonathan A. Winger(8), Catherine Bédard(6), Carol Liang(5), Kevin Tanaka(4), Tim Keating(4), Nicholas Butowski(4), Andrew Davis(3), Laura Serwer(3), Michael S. Kent(3), J.J. Getz(2), Feng Yan(2), Teri Guerrero(2), Peter J. Dickinson(2), Kevin G. Leong(2), Youngho Seo(2)