Linda S. Steelman

Biochemistry, Genetics and Molecular Biology · Life Sciences

56h-index16.2kcitations150works0.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(51), Melanoma and MAPK Pathways(34), Cytokine Signaling Pathways and Interactions(29), Cancer-related Molecular Pathways(26), Synthesis and biological activity(18)

Publications150 total

OS09.4.A EARLY TUMOR VOLUME CHANGES PREDICT CLINICAL OUTCOMES IN MIDH1/2 GLIOMA: POST-HOC RESULTS FROM THE PHASE 3 INDIGO TRIAL
Neuro-Oncology·2025Open Access
A.6 INDIGO: a global, randomized, double-blinded, Phase 3 study of vorasidenib versus placebo in patients with grade 2 glioma with an IDH1/2 mutation (mIDH1/2)
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques·2024Open Access
498O INDIGO: A randomized, double-blinded, phase III study of vorasidenib versus placebo in IDH1 or IDH2 low-grade glioma
Annals of Oncology·2023· 2 citedOpen Access
Effects of TP53 Mutations and miRs on Immune Responses in the Tumor Microenvironment Important in Pancreatic Cancer Progression
Cells·2022· 47 citedOpen Access
Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties
Aging·2022· 9 citedOpen Access
Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53
Cells·2022· 17 citedOpen Access
APR-246—The Mutant TP53 Reactivator—Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells
Biomolecules·2022· 9 citedOpen Access
Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of WT-TP53
Advances in Biological Regulation·2021· 9 citedOpen Access
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals
Cells·2021· 23 citedOpen Access
Sensitivity of pancreatic cancer cells to chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals can be regulated by WT-TP53
Advances in Biological Regulation·2021· 7 cited
Therapeutic resistance in breast cancer cells can result from deregulated EGFR signaling
Advances in Biological Regulation·2020· 38 citedOpen Access
Cancer therapy and treatments during COVID-19 era
Advances in Biological Regulation·2020· 47 citedOpen Access
GSK-3 and miRs: Master regulators of therapeutic sensitivity of cancer cells
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2020· 16 cited
Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines
Aging·2020· 28 citedOpen Access
Targeting GSK3 and Associated Signaling Pathways Involved in Cancer
Cells·2020· 254 citedOpen Access
New landscapes and horizons in hepatocellular carcinoma therapy
Aging·2020· 56 citedOpen Access
RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma
Expert Opinion on Therapeutic Targets·2019· 93 cited
Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells
Advances in Biological Regulation·2019· 12 cited
Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells
Advances in Biological Regulation·2019· 40 cited
Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals
Advances in Biological Regulation·2019· 11 cited
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Frequent Co-authors

James A. McCubrey(50), Massimo Libra(33), Alberto M. Martelli(30), Stephen L. Abrams(25), Ferdinando Nicoletti(22), Melchiorre Cervello(19), Franca Stivala(18), Jörg Bäsecke(18), Lucio Cocco(18), William H. Chappell(17), Giuseppe Montalto(17), Richard A. Franklin(15), Michèle Milella(10), Agostino Tafuri(9), Camilla Evangelisti(9), Saverio Candido(9), Patrick M. Navolanic(8), Ellis W.T. Wong(6), David M. Terrian(6), William L. Blalock(6)