Bruce A. Malcolm

Janssen (Belgium) — Belgium

Medicine · Health Sciences

30h-index4.3kcitations81works0.02yr avg
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Research Topics

Hepatitis C virus research(33), Monoclonal and Polyclonal Antibodies Research(19), Hepatitis B Virus Studies(14), HIV/AIDS drug development and treatment(13), Viral Infections and Immunology Research(9)

Publications81 total

PrEP-001 prophylactic effect against rhinovirus and influenza virus - RESULTS of 2 randomized trials
Antiviral Research·2018· 14 citedOpen Access
Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology
European Journal of Pharmaceutics and Biopharmaceutics·2015· 8 cited
Coaching for Autonomy in a Graduate-level TEFL Reading Course in Japan
2015
The influence of saline concentration on the success of Calcein marking techniques for hatchery-produced Murray cod (Maccullochella peelii)
Journal and proceedings of the Royal Society of New South Wales·2012· 7 citedOpen Access
Reporter gene expression from LTR-circles as tool to identify HIV-1 integrase inhibitors
Journal of Virological Methods·2012· 9 cited
The influence of saline concentration on the success of Calcein marking techniques for hatchery-produced Murray cod (Maccullochella peelii)
Charles Sturt University Research Output (CRO)·2012Open Access
Screening and rank ordering of reversible mechanism‐based inhibitors of Hepatitis C virus NS3 protease using electrospray ionization mass spectrometry
Journal of Mass Spectrometry·2011· 2 cited
A comparative analysis of the substrate permissiveness of HCV and GBV-B NS3/4A proteases reveals genetic evidence for an interaction with NS4B protein during genome replication
Virology·2010· 10 cited
Preclinical Characterization of the Antiviral Activity of SCH 900518 (Narlaprevir), a Novel Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease
Antimicrobial Agents and Chemotherapy·2010· 46 citedOpen Access
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor
ACS Medicinal Chemistry Letters·2010· 95 citedOpen Access
967 PRECLINICAL CHARACTERIZATION OF SCH 900518, A NOVEL MECHANISM-BASED INHIBITOR OF HCV NS3 PROTEASE
Journal of Hepatology·2009· 1 citedOpen Access
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034
Journal of Synchrotron Radiation·2008· 2 citedOpen Access
Discovery of the HCV NS3/4A Protease Inhibitor (1<i>R</i>,5<i>S</i>)-<i>N</i>-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(<i>S</i>)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(<i>S</i>)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization
Journal of Medicinal Chemistry·2007· 106 citedOpen Access
Structure of the HCV NS3/4A Protease Inhibitor CVS4819
2006
Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH571696
2006
Structure of NS3 complexed with a ketoamide inhibitor SCh491762
2006
Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034
2006
Discovery of the HCV NS3/4A Protease Inhibitor SCH503034. Key Steps in Structure-Based Optimization
2006
Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
Journal of Medicinal Chemistry·2006· 278 citedOpen Access
SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
Antimicrobial Agents and Chemotherapy·2006· 316 citedOpen Access
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Frequent Co-authors

F. George Njoroge(9), Andrew Prongay(8), Vincent Madison(8), Xiao Tong(6), Srikanth Venkatraman(6), Frank Bennett(6), Robert A. Chase(5), John Pichardo(5), Viyyoor Girijavallabhan(5), Stéphane Bogen(5), Ashok Arasappan(5), Brian M. Beyer(5), Frederick Lahser(4), Angela Skelton(4), Ellen Xia(4), Anil K. Saksena(4), Jack F. Kirsch(4), Rumin Zhang(4), John C. Vederas(4), Nancy Butkiewicz(3)