Nancy Butkiewicz

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

17h-index1.2kcitations36works0.02yr avg
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Research Topics

Hepatitis C virus research(29), HIV/AIDS drug development and treatment(17), Hepatitis B Virus Studies(14), Monoclonal and Polyclonal Antibodies Research(13), Biochemical and Molecular Research(5)

Publications36 total

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles
Bioorganic & Medicinal Chemistry Letters·2011· 49 cited
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue
Bioorganic & Medicinal Chemistry·2007· 6 cited
Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
Journal of Medicinal Chemistry·2006· 278 citedOpen Access
P2–P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease
Bioorganic & Medicinal Chemistry Letters·2006· 22 citedOpen Access
Novel Inhibitors of Hepatitis C NS3—NS4A Serine Protease Derived from 2‐Aza‐bicyclo[2.2.1]heptane‐3‐carboxylic Acid.
ChemInform·2006· 1 cited
HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
2006
SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
Antimicrobial Agents and Chemotherapy·2006· 316 citedOpen Access
Novel inhibitors of hepatitis C NS3–NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid
Bioorganic & Medicinal Chemistry Letters·2006· 26 citedOpen Access
Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycles
Journal of Medicinal Chemistry·2006· 38 citedOpen Access
Potent 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease
Journal of Medicinal Chemistry·2005· 42 citedOpen Access
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane
2005
Design, Synthesis, and Biological Activity of <i>m</i>-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease
Journal of Medicinal Chemistry·2005· 27 citedOpen Access
Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2–P1 cyclopropyl alanine combination for improved potency
Bioorganic & Medicinal Chemistry Letters·2005· 26 citedOpen Access
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si2.gif" overflow="scroll"><mml:mrow><mml:msubsup><mml:mrow><mml:mi mathvariant="normal">P</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math> moiety with improved potency
Bioorganic & Medicinal Chemistry Letters·2005· 27 citedOpen Access
Novel inhibitors of the hepatitis C virus NS3 proteinase
Bioorganic & Medicinal Chemistry Letters·2005· 3 cited
Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design
Journal of Medicinal Chemistry·2005· 29 citedOpen Access
HCV NS3 Protease Domain with a Ketoamide Inhibitor Covalently bound.
2005
Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound
2005
Aminothiazole inhibitors of HCV RNA polymerase
Bioorganic & Medicinal Chemistry Letters·2004· 12 citedOpen Access
Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex
Bioorganic & Medicinal Chemistry Letters·2004· 17 citedOpen Access
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Frequent Co-authors

John Pichardo(21), Viyyoor Girijavallabhan(20), F. George Njoroge(18), Andrew Prongay(16), Srikanth Venkatraman(12), Ashok Arasappan(10), Andrea Hart(8), Frank Bennett(8), Vincent Madison(8), Bimalendu Dasmahapatra(8), Nanhua Yao(7), Kevin X. Chen(6), Mahesh Patel(6), Tze‐Ming Chan(5), Haifeng Gu(5), Bruce A. Malcolm(4), Stéphane Bogen(4), Tejal N. Parekh(4), Patrick Pinto(4), Bancha Vibulbhan(4)