Nanhua Yao

Medicine · Health Sciences

29h-index3.1kcitations57works28.02yr avg
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Research Topics

Hepatitis C virus research(30), HIV/AIDS drug development and treatment(17), Hepatitis B Virus Studies(12), Biochemical and Molecular Research(9), Computational Drug Discovery Methods(8)

Publications56 total

Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors
Biochemical and Biophysical Research Communications·2013· 6 cited
Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain
ChemMedChem·2013· 47 cited
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 14 citedOpen Access
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 21 citedOpen Access
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates
Bioorganic & Medicinal Chemistry Letters·2013· 11 citedOpen Access
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Bioorganic & Medicinal Chemistry Letters·2011· 32 citedOpen Access
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bioorganic & Medicinal Chemistry Letters·2011· 38 citedOpen Access
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration
Bioorganic & Medicinal Chemistry Letters·2010· 44 citedOpen Access
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK
Bioorganic & Medicinal Chemistry Letters·2010· 29 citedOpen Access
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region
Bioorganic & Medicinal Chemistry Letters·2010· 25 citedOpen Access
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents
Bioorganic & Medicinal Chemistry Letters·2010· 25 citedOpen Access
ChemInform Abstract: Synthesis of Tipranavir Analogues as Non‐Peptidic HIV Protease Inhibitors.
ChemInform·2009
Synthesis of Tipranavir Analogues as Non-Peptidic HIV Protease Inhibitors
Letters in Organic Chemistry·2009· 6 cited
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034
Journal of Synchrotron Radiation·2008· 2 citedOpen Access
Identification and Structure—Activity Relationships of Substituted Pyridones as Inhibitors of Pim‐1 Kinase.
ChemInform·2007· 6 citedOpen Access
Discovery of the HCV NS3/4A Protease Inhibitor (1<i>R</i>,5<i>S</i>)-<i>N</i>-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(<i>S</i>)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(<i>S</i>)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization
Journal of Medicinal Chemistry·2007· 106 citedOpen Access
Corrigendum to “Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase” [Bioorg. Med. Chem. Lett. 17 (2007) 841–845]
Bioorganic & Medicinal Chemistry Letters·2007· 5 cited
Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study
Bioorganic & Medicinal Chemistry Letters·2007· 48 cited
Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase
Bioorganic & Medicinal Chemistry Letters·2007· 170 citedOpen Access
Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2006· 55 cited
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Frequent Co-authors

Zhi Hong(15), Jim Zhen Wu(12), Dean R. Artis(11), Roy K. Hom(10), Hing L. Sham(10), T.C. Appleby(9), Simeon Bowers(9), Hu Pan(9), Lany Ruslim(9), Andrei W. Konradi(9), Gary D. Probst(9), Robert Hamatake(8), Shunqi Yan(7), Anh P. Truong(7), Michael P. Bova(7), Zhao Ren(7), Kevin P. Quinn(7), John‐Michael Sauer(7), Ted Yednock(7), Nancy Butkiewicz(7)