Melanie Allen

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index888citations18works8.02yr avg
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Research Topics

CRISPR and Genetic Engineering(5), CAR-T cell therapy research(5), Neuroscience and Neuropharmacology Research(2), Hemoglobinopathies and Related Disorders(2), Protease and Inhibitor Mechanisms(2)

Publications18 total

CTX112, a Next-Generation Allogeneic CRISPR-Cas9 Engineered CD19 CAR T Cell with Novel Potency Edits: Data from Phase 1 Dose Escalation Study in Patients with Relapsed or Refractory B-Cell Malignancies
Blood·2024· 8 citedOpen Access
274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency
Regular and Young Investigator Award Abstracts·2023· 1 citedOpen Access
Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors
Cancer Research·2023· 13 cited
Abstract 3243: Allogeneic anti-PTK7 CAR-T cells for the treatment of solid tumors
Cancer Research·2020· 4 cited
Abstract 2551: Allogeneic CRISPR engineered anti CD70 CAR T cells demonstrate potent preclinical activity against both solid and hematological cancer cells
Cancer Research·2018· 1 cited
Crispr/Cas9- Mediated Genome Editing of Human CD34+ Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies
Blood·2016· 3 cited
Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) to Treat Sickle Cell Disease (SCD) and β-Thalassemia
Blood·2016· 4 cited
Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy
The American Journal of Human Genetics·2016· 80 citedOpen Access
Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation
Synapse·2008· 91 citedOpen Access
Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice
Journal of Allergy and Clinical Immunology·2006· 44 citedOpen Access
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine
Brain Research·2003· 104 cited
Engineering Autoactivating Forms of Matrix Metalloproteinase-9 and Expression of the Active Enzyme in Cultured Cells and Transgenic Mouse Brain
Biochemistry·2002· 20 cited
Detection of Bradykinin and Bradykinin-β2 Receptors in the Porcine Endometrium During the Estrous Cycle and Early Pregnancy1
Biology of Reproduction·2002· 14 citedOpen Access
Glycemic Control in Mice with Targeted Disruption of the Glucagon Receptor Gene
Biochemical and Biophysical Research Communications·2002· 157 cited
Presence of the Acute Phase Protein, Bikunin, in the Endometrium of Gilts During Estrous Cycle and Early Pregnancy1
Biology of Reproduction·2001· 71 citedOpen Access
Deficiency of the Stress Kinase P38α Results in Embryonic Lethality
The Journal of Experimental Medicine·2000· 268 citedOpen Access
Phenotypic characterization and analysis of allogeneic T cell responses in ZAP-70 dominant negative transgenic mice
Clinical & Experimental Immunology·1997· 5 citedOpen Access
Screening of ‘unbiased’ immobilized peptide library vs. proteases: An approach for rapid determination of substrate specificity and selectivity
1995

Frequent Co-authors

Jeffrey L. Stock(3), Jonathan Terrett(3), Demetrios Kalaitzidis(3), Zinkal Padalia(3), Henia Dar(3), Elaine Huang(3), Alana M. Weaver(3), John McNeish(2), John D. McNeish(2), Christine A. Strick(2), Andrea M. Hettinger(2), Bing R. Zhang(2), David Goad(2), Jerry R. Malayer(2), Rodney D. Geisert(2), Mary‐Lee Dequéant(2), Sushant Karnik(2), Mohammed G. Ghonime(2), Robert Chain(2), Nivedita Jaishankar(2)