Shin‐ichiro Nagatsuka

Sekisui Medical (Japan) — Japan

Medicine · Health Sciences

17h-index1.5kcitations41works0.02yr avg
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Research Topics

Cholinesterase and Neurodegenerative Diseases(12), Medical Imaging Techniques and Applications(6), Neuroscience and Neuropharmacology Research(5), Computational Drug Discovery Methods(5), Antioxidant Activity and Oxidative Stress(5)

Publications41 total

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice
PLoS ONE·2015· 137 citedOpen Access
Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse® with highly humanized liver
Toxicology Letters·2014· 1 cited
Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters
Pharmacogenetics and Genomics·2014· 20 cited
Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-Mouse® with highly humanized liver
Toxicology Letters·2013· 1 cited
Pharmacokinetics and Metabolism of Radiolabelled SNI-2011, a Novel Muscarinic Receptor Agonist, in Healthy Volunteers
Arzneimittelforschung·2011· 6 cited
HUMAN-SPECIFIC METABOLITE IN DICLOFENAC-TREATED CHIMERIC PXB MICE WITH HIGHLY HUMANIZED LIVER
Medical Entomology and Zoology·2010
Monte Carlo simulation for reference tissue-based linear analysis of [<sup>11</sup>C]MP4A AND [<sup>11</sup>C]MP4P: Assessment of optimal regions and optimization for precise measurement of brain AChE activity
Journal of Cerebral Blood Flow & Metabolism·2005
Estimation of Plasma IC50 of Donepezil Hydrochloride for Brain Acetylcholinesterase Inhibition in Monkey Using N-[11C]methylpiperidin-4-yl Acetate ([11C]MP4A) and PET
Neuropsychopharmacology·2005· 28 citedOpen Access
Disposition of low doses of 14C-bisphenol A in male, female, pregnant, fetal, and neonatal rats
Archives of Toxicology·2004· 57 cited
Evaluation of Simplified Kinetic Analyses for Measurement of Brain Acetylcholinesterase Activity Using <i>N</i>-[<sup>11</sup>C]Methylpiperidin-4-yl Propionate and Positron Emission Tomography
Journal of Cerebral Blood Flow & Metabolism·2004· 12 citedOpen Access
Acetylcholinesterase Imaging: Its Use in Therapy Evaluation and Drug Design
Current Pharmaceutical Design·2004· 39 cited
A simple method for the detection of abnormal brain regions in Alzheimer’s disease patients using [11C]MP4A: Comparison with [123I]IMP SPECT
Annals of Nuclear Medicine·2004· 14 cited
Reference-Tissue-Based Kinetic Analysis of [11C]MP4A PET Data without Arterial Input Function
Elsevier eBooks·2002· 1 cited
Pixel-by-Pixel Mapping of Acetylcholinesterase Activity in Human Brain with [11C]MP4A/PET
Elsevier eBooks·2002· 1 cited
Kinetic Analysis of [<sup>11</sup>C]MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity without Arterial Blood Sampling
Journal of Cerebral Blood Flow & Metabolism·2001· 49 citedOpen Access
MRI based ROI evaluation of MP4A-PET images
NeuroImage·2001
Positron Emission Tomographic Measurement of Brain Acetylcholinesterase Activity Using <i>N</i>-[<sup>11</sup>C]methylpiperidin-4-yl Acetate Without Arterial Blood Sampling: Methodology of Shape Analysis and its Diagnostic Power for Alzheimer's Disease
Journal of Cerebral Blood Flow & Metabolism·2001· 37 cited
Synthesis of piperidinyl and pyrrolidinyl butyrates for potential <i>In Vivo</i> measurement of cerebral butyrylcholinesterase activity
Journal of Labelled Compounds and Radiopharmaceuticals·2001· 14 cited
In vivo mapping of brain cholinergic function in Parkinson's disease and progressive supranuclear palsy.
PubMed·2001· 16 cited
Tracer Conversion Rate and Accuracy of Compartmental Model Parameter in Irreversibly Trapped Radiotracer Method
Elsevier eBooks·2001
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Frequent Co-authors

Kiyoshi Fukushi(19), Toshiaki Irie(19), Hitoshi Shinotoh(17), Hiroki Namba(14), Noriko Tanaka(12), Shuji Tanada(12), Masaomi Iyo(11), Akiyo Aotsuka(9), Tsuneyoshi Ota(9), T. NAKAZAWA(7), Osami Yukawa(4), Tetsuya Shiraishi(4), Kōichi Sato(4), Noriaki Shimada(4), Shinichi Ninomiya(3), Tetsuya Suhara(2), Yasuhiko Sudo(2), Kazutoshi Suzuki(2), Mika Yamaguchi(2), Takamichi Hattori(2)