Gillian M. Lamont

AstraZeneca (Singapore) — Singapore

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.6kcitations34works9.92yr avg
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Research Topics

Cancer therapeutics and mechanisms(5), DNA Repair Mechanisms(4), Protein Kinase Regulation and GTPase Signaling(4), Catalytic Cross-Coupling Reactions(4), PI3K/AKT/mTOR signaling in cancer(4)

Publications34 total

Discovery of AZD9750, an Orally Bioavailable Androgen Receptor Degrader for the Treatment of Prostate Cancer
Journal of Medicinal Chemistry·2026
Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome
Journal of Medicinal Chemistry·2025· 2 cited
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor
Journal of Medicinal Chemistry·2025· 15 cited
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors
RSC Medicinal Chemistry·2025Open Access
Discovery and <i>In Vivo</i> Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity
Journal of Medicinal Chemistry·2024· 18 citedOpen Access
Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer
Journal of Medicinal Chemistry·2024· 6 cited
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC
Communications Biology·2024· 19 citedOpen Access
Development of a Series of Pyrrolopyridone MAT2A Inhibitors
Journal of Medicinal Chemistry·2024· 11 citedOpen Access
AiZynth impact on medicinal chemistry practice at AstraZeneca
RSC Medicinal Chemistry·2024· 18 citedOpen Access
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS<sup>G12C</sup> with Demonstrable CNS Penetration
Journal of Medicinal Chemistry·2023· 27 citedOpen Access
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit
ACS Chemical Biology·2023· 11 cited
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology
Journal of Medicinal Chemistry·2022· 53 citedOpen Access
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8<i>H</i>-purin-8-one Inhibitors of DNA-PK
ACS Medicinal Chemistry Letters·2022· 11 citedOpen Access
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS<sup>G12C</sup>
Journal of Medicinal Chemistry·2022· 56 citedOpen Access
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-<i>a</i>]pyridin-6-yl)amino]-9-(tetrahydro-2<i>H</i>-pyran-4-yl)-7,9-dihydro-8<i>H</i>-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Journal of Medicinal Chemistry·2019· 77 citedOpen Access
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
Nature Communications·2019· 327 citedOpen Access
Abstract DDT01-02: Discovery and first structural disclosure of AZD7648: A potent and selective DNA-PK inhibitor
Molecular and Cellular Biology / Genetics·2019· 1 cited
Abstract DDT01-02: Discovery and first structural disclosure of AZD7648: A potent and selective DNA-PK inhibitor
Cancer Research·2019· 1 cited
Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors
ACS Medicinal Chemistry Letters·2016· 27 citedOpen Access
Correction to Investigation of (<i>E</i>)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators
Journal of Medicinal Chemistry·2016Open Access
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Frequent Co-authors

Frederick W. Goldberg(16), Paul D. Kemmitt(12), Kevin Blades(8), Matthew Box(7), Mercedes Vázquez–Chantada(7), Barry R. Davies(7), Jason G. Kettle(7), Charlene Fallan(7), James S. Scott(7), David T. Beattie(6), Rachel Howells(6), M. Raymond V. Finlay(5), Scott G. Lamont(5), Antonio Ramos‐Montoya(5), Emma Dean(5), Elaine Cadogan(5), Claire Crafter(5), Attilla Ting(5), Marianne Schimpl(5), Derek Barratt(5)