Paul D. Kemmitt

AstraZeneca (United Kingdom) — United Kingdom

Materials Science · Physical Sciences

20h-index1.9kcitations94works10.02yr avg
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Research Topics

Crystallization and Solubility Studies(31), X-ray Diffraction in Crystallography(31), Catalytic C–H Functionalization Methods(12), Catalytic Cross-Coupling Reactions(9), Crystallography and molecular interactions(7)

Publications94 total

Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters
Angewandte Chemie·2025Open Access
Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters
Angewandte Chemie International Edition·2025· 6 citedOpen Access
Discovery and <i>In Vivo</i> Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity
Journal of Medicinal Chemistry·2024· 18 citedOpen Access
A directed enolization strategy enables by-product-free construction of contiguous stereocentres en route to complex amino acids
Nature Chemistry·2024· 16 citedOpen Access
CCDC 2277416: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
Access to a Diverse Array of Bridged Benzo[1,5]oxazocine and Benzo[1,4]diazepine Structures
Organic Letters·2023· 1 citedOpen Access
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS<sup>G12C</sup> with Demonstrable CNS Penetration
Journal of Medicinal Chemistry·2023· 27 citedOpen Access
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors
Bioorganic & Medicinal Chemistry Letters·2023· 5 citedOpen Access
Graphical Abstract: Angew. Chem. Int. Ed. 2/2023
Angewandte Chemie International Edition·2023Open Access
Optimization of a Series of Novel, Potent and Selective Macrocyclic SYK Inhibitors
SSRN Electronic Journal·2023Open Access
Visible Light‐Mediated Cyclisation Reaction for the Synthesis of Highly‐Substituted Tetrahydroquinolines and Quinolines
Angewandte Chemie·2022· 2 cited
Visible Light‐Mediated Cyclisation Reaction for the Synthesis of Highly‐Substituted Tetrahydroquinolines and Quinolines
Angewandte Chemie International Edition·2022· 26 citedOpen Access
CCDC 2084176: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS<sup>G12C</sup>
Journal of Medicinal Chemistry·2022· 56 citedOpen Access
Atom and step economical synthesis of acyclic quaternary centers <i>via</i> iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes
Chemical Science·2022· 14 citedOpen Access
Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy
Communications Biology·2021· 89 citedOpen Access
Deliberately Losing Control of C−H Activation Processes in the Design of Small‐Molecule‐Fragment Arrays Targeting Peroxisomal Metabolism
ChemMedChem·2020· 6 citedOpen Access
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors
Bioorganic & Medicinal Chemistry Letters·2020· 9 cited
Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase
Bioorganic & Medicinal Chemistry Letters·2020· 5 citedOpen Access
CCDC 1973034: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
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Frequent Co-authors

Frederick W. Goldberg(10), Gillian M. Lamont(9), Graeme R. Robb(9), John Spencer(9), Scott G. Lamont(8), Michael J. Waring(8), William McCoull(8), Matthew Box(6), Shaun Fillery(6), Piotr Raubo(6), Kevin Blades(6), Andrew V. Turnbull(6), Scott Boyd(6), Robert Felix(6), Rodrigo J. Carbajo(5), Andrew D. Ferguson(5), Martin Howard(5), Lyman J. Feron(5), Alan M. Birch(5), Susan Birtles(5)