Marzena Dyba

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.1kcitations36works2.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(9), Glycosylation and Glycoproteins Research(7), Monoclonal and Polyclonal Antibodies Research(6), Protein Degradation and Inhibitors(5), RNA and protein synthesis mechanisms(3)

Publications36 total

Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis
Angiogenesis·2025· 5 citedOpen Access
Angulin-1/LSR inhibition transiently disrupts the blood-tumor barrier to enhance doxil permeability and impair malignant glioma progression
2025· 1 citedOpen Access
Elucidation and Prevention of an Unexpected Methylamine Byproduct Formed During Trifluoroacetic Acid-Mediated Side Chain Deprotection of Azido-Containing Peptides
International Journal of Peptide Research and Therapeutics·2025
Elucidation and prevention of an unexpected methylamine byproduct formed during trifluoroacetic acid-mediated side chain deprotection of azido-containing peptides
2025Open Access
Optimized isolation of enzymatically active ubiquitin E3 ligase E6AP/UBE3A from mammalian cells
Protein Expression and Purification·2025· 1 cited
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins
UNC Libraries·2024Open Access
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins
Nature Communications·2024· 7 citedOpen Access
hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
Molecular Cell·2023· 13 citedOpen Access
Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
Cell Reports·2023· 24 citedOpen Access
Human γS-Crystallin Mutation F10_Y11delinsLN in the First Greek Key Pair Destabilizes and Impairs Tight Packing Causing Cortical Lamellar Cataract
International Journal of Molecular Sciences·2023· 2 citedOpen Access
The Y46D Mutation Destabilizes Dense Packing of the Second Greek Key Pair of Human γC-Crystallin Causing Congenital Nuclear Cataracts
Biochemistry·2023· 4 citedOpen Access
Detailed mechanism of catalysis by tetrameric <scp>L</scp>-glutaminase-asparaginase from <i>Pseudomonas</i> 7A (PGA)
Acta Crystallographica Section A Foundations and Advances·2022Open Access
Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma
Nature Communications·2021· 33 citedOpen Access
Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma
2021· 2 citedOpen Access
Generalized enzymatic mechanism of catalysis by tetrameric l-asparaginases from mesophilic bacteria
Scientific Reports·2020· 23 citedOpen Access
Design and Generation of Self-Assembling Peptide Virus-like Particles with Intrinsic GPCR Inhibitory Activity
Methods in molecular biology·2020· 2 citedOpen Access
Heavy-atom labeling of RNA by PLOR for de novo crystallographic phasing
PLoS ONE·2019· 10 citedOpen Access
Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer
ACS Omega·2018· 35 citedOpen Access
Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets
Nature Communications·2017· 86 citedOpen Access
Structure of hRpn13 at the Proteasome
The FASEB Journal·2017
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Frequent Co-authors

Sergey G. Tarasov(16), Kylie J. Walters(9), Nadya I. Tarasova(8), Xiuxiu Lu(8), Charles D. Schwieters(6), Rolf E. Swenson(6), Yun‐Xing Wang(5), Dimiter S. Dimitrov(5), Venkata R. Sabbasani(5), Þorkell Andrésson(5), Raj Chari(5), Ping Yu(4), Zhongyu Zhu(4), Sudipto Das(4), Hiroshi Matsuo(4), Vadim Gaponenko(3), Jinbu Wang(3), Yu Liu(3), Jason R. Stagno(3), Yang Feng(3)