Jonathon D. Sedgwick

Boehringer Ingelheim (Taiwan) — Taiwan

Immunology and Microbiology · Life Sciences

59h-index18.4kcitations107works0.02yr avg
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Research Topics

T-cell and B-cell Immunology(39), Immunotherapy and Immune Responses(24), Immune Cell Function and Interaction(23), Immune Response and Inflammation(20), Neuroinflammation and Neurodegeneration Mechanisms(18)

Publications107 total

Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses
OncoImmunology·2022· 21 citedOpen Access
Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases
JCO Precision Oncology·2021· 127 citedOpen Access
Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist
Cancer Research·2020· 5 cited
The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling
Frontiers in Immunology·2018· 75 citedOpen Access
Abstract 4547: Characterization of the LAG-3 targeting antibody BI 754111 in monotherapy and in combination with the anti-PD-1 antibody BI 754091
Cancer Research·2018· 5 cited
Abstract 4558: In vitro and in vivo characterization of the PD-1 targeting antibody BI 754091
Cancer Research·2018· 1 cited
Loss of TNF Signaling Facilitates the Development of a Novel Ly-6Clow Macrophage Population Permissive for <i>Leishmania major</i> Infection
The Journal of Immunology·2012· 20 cited
A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
Nature Immunology·2008· 461 cited
STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
Journal of Clinical Investigation·2008· 348 citedOpen Access
Differential Requirements by CD4+ and CD8+ T Cells for Soluble and Membrane TNF in Control of <i>Francisella tularensis</i> Live Vaccine Strain Intramacrophage Growth
The Journal of Immunology·2007· 32 cited
CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts
Proceedings of the National Academy of Sciences·2007· 72 citedOpen Access
Monoclonal Antibody-Mediated CD200 Receptor Signaling Suppresses Macrophage Activation and Tissue Damage in Experimental Autoimmune Uveoretinitis
American Journal Of Pathology·2007· 145 citedOpen Access
The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation [Current Opinion in Immunology 2006, 18:670–675]
Current Opinion in Immunology·2006· 16 cited
The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation
Current Opinion in Immunology·2006· 298 cited
TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis
The Journal of Immunology·2006· 36 citedOpen Access
Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction
Acta Neuropathologica·2006· 86 cited
Mast Cell-Associated TNF Promotes Dendritic Cell Migration
The Journal of Immunology·2006· 265 citedOpen Access
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase Cθ-Deficient Mice
The Journal of Immunology·2006· 132 citedOpen Access
Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF
The Journal of Immunology·2006· 422 cited
Regulation of Myeloid Cell Function through the CD200 Receptor
The Journal of Immunology·2006· 223 cited
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Frequent Co-authors

Heinrich Körner(15), Robert M. Hoek(7), Sean Riminton(5), Joseph H. Phillips(5), Craig A. Murphy(4), Sigrid R. Ruuls(4), A. Neil Barclay(4), Holly Cherwinski(4), Frances A. Lemckert(4), Patrick G. Holt(4), Linda Lucian(3), Sérgio A. Lira(3), Vu N. Ngo(3), Jason G. Cyster(3), Gavin J. Wright(3), Marion H. Brown(3), Michael J. Puklavec(3), Maria C. Jenmalm(3), Susumu Nakae(3), Hajime Suto(3)