Simon Knott

Cedars-Sinai Medical Center — United States

Medicine · Health Sciences

31h-index4.4kcitations114works8.52yr avg
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Research Topics

Cancer Immunotherapy and Biomarkers(23), Epigenetics and DNA Methylation(11), Single-cell and spatial transcriptomics(11), DNA Repair Mechanisms(8), Immune cells in cancer(8)

Publications113 total

Abstract B034: Single-cell immune profiling reveals T cell dynamics in estrogen receptor–positive breast cancer treated with anti-PD-1 and radiation therapy
Cancer Research·2026
EZH2 Inhibitors Sensitize Breast Cancer to HER2 Kinase Inhibitors through Cooperative Effects on YAP and Pro-apoptotic Regulators
Cancer Research·2026
Lesion-remote astrocytes govern microglia-mediated white matter repair
Nature·2025· 2 citedOpen Access
Asparagine bioavailability governs metastasis in a model of breast cancer
UNC Libraries·2025Open Access
673 Dual checkpoint blockade enhances antitumor immunity in triple-negative breast cancer by potentiating CD8 <sup>+</sup> T cell function and inducing clonal expansion
Regular and Young Investigator Award Abstracts·2025Open Access
Charting the tumor antigen landscape of breast cancer by high-throughput antigen screening 2580
The Journal of Immunology·2025Open Access
1111 Single-cell-driven design of logic-gated CAR circuits for enhanced solid tumor immunotherapy
Regular and Young Investigator Award Abstracts·2025Open Access
Abstract C042: Systematic discovery of logic-gated cell surface targets for enhanced solid tumor CAR therapy through single-cell transcriptomics
Molecular Cancer Therapeutics·2025
EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer
2025Open Access
EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer
2025Open Access
Author Correction: IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages
Nature Cancer·2025· 2 citedOpen Access
An immunological mechanism of resistance to CDK4/6 inhibitors in HR <sup>+</sup> breast cancer
OncoImmunology·2025Open Access
Abstract B047: Path2Space: An AI approach for cancer biomarker discovery via histopathology inferred spatial transcriptomics
Clinical Cancer Research·2025
IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages
Nature Cancer·2025· 10 cited
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
Nature·2025· 18 citedOpen Access
The mutational landscape defines the proteome and spatial organization of tumor, stroma and immune cells in ovarian cancer
2025Open Access
A macrophage-neutrophil program drives mammary carcinogenesis
Trends in cancer·2025
IP14-09 Y CHROMOSOME LOSS PROMOTES NEUROENDOCRINE DIFFERENTIATION IN BLADDER CANCER
The Journal of Urology·2025
Assessing the implementation of a pilot competency framework for advanced clinical practitioners in general practice
International Journal for Advancing Practice·2025
Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy
2025· 6 citedOpen Access
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Frequent Co-authors

Gregory J. Hannon(13), Nicolas Erard(8), Kenneth Gouin(8), Oscar M. Aparicio(8), Christopher J. Viggiani(6), Simon Tavaré(6), Stephen L. Shiao(6), Elvin Wagenblast(5), Ashley R. Maceli(4), Dan Theodorescu(4), Reva Basho(4), Heather L. McArthur(4), Sun Y. Kim(3), Mar Soto(3), Annika L. Gable(3), Steffen Dickopf(3), John E. Wilkinson(3), J. Chuck Harrell(3), Charles M. Perou(3), Hani Goodarzi(3)