Robin Handon

National Human Genome Research Institute — United States

Immunology and Microbiology · Life Sciences

11h-index2.6kcitations20works0.02yr avg
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Research Topics

Immune Cell Function and Interaction(16), T-cell and B-cell Immunology(12), Asthma and respiratory diseases(4), CAR-T cell therapy research(4), IL-33, ST2, and ILC Pathways(4)

Publications20 total

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
Cell Reports·2021· 28 citedOpen Access
Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection
Nature Immunology·2019· 546 cited
Mg2+ regulation of kinase signaling and immune function
The Journal of Experimental Medicine·2019· 81 cited
Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity
Nature Immunology·2018· 89 citedOpen Access
A delicate balance of PI3K activation is required for CD8 T cell survival and generation of memory cells
The Journal of Immunology·2017
Dissecting the role of Phosphotidylinositol 3-Kinase (PI3K) δ in the germinal center reaction through a mouse model of hyperactivated <i>Pik3cd</i>
The Journal of Immunology·2017
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
The Journal of Immunology·2017· 2 cited
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
Science Immunology·2016· 615 citedOpen Access
An essential role for Itk in Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
The Journal of Immunology·2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
Nature Communications·2016· 80 citedOpen Access
The Tec family kinase Itk is required for Th9 cell differentiation (LYM8P.642)
The Journal of Immunology·2015
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
The Journal of Experimental Medicine·2014· 174 citedOpen Access
Cross-talk between T cell receptor and cytokine signaling is mediated by Itk: implications for the balance between Th17 and regulatory T cells (P1141)
The Journal of Immunology·2013
Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition
Immunity·2011· 401 citedOpen Access
Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells
Immunity·2011· 252 citedOpen Access
An Alternative Method for Intrathymic Injection in Mice (144.8)
The Journal of Immunology·2010
Differential expression of IL-17A and IL-17F is coupled to TCR signaling via Itk-mediated regulation of NFATc1 (139.4)
The Journal of Immunology·2010· 1 cited
Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase
Immunity·2009· 205 citedOpen Access
Requirements for Selection of Conventional and Innate T Lymphocyte Lineages
Immunity·2007· 93 citedOpen Access
The Tec kinase Itk regulates conventional versus non-conventional CD8 T cell development (87.14)
The Journal of Immunology·2007

Frequent Co-authors

Pamela L. Schwartzberg(15), Stacie M. Anderson(10), Julio Gómez‐Rodríguez(10), Martha Kirby(9), Jennifer L. Cannons(7), Julie Reilley(6), Françoise Meylan(5), Tuoqi Wu(4), John J. O’Shea(4), Silvia Preite(4), Erika Hayes(4), Dorian B. McGavern(3), Hong‐Wei Sun(3), Yasmine Belkaid(3), Gülbû Uzel(3), Senta M. Kapnick(3), Yun Ji(2), E. Ashley Moseman(2), Abdel G. Elkahloun(2), Luca Gattinoni(2)