Jennifer L. Cannons

National Institute of Allergy and Infectious Diseases — United States

Immunology and Microbiology · Life Sciences

37h-index9.1kcitations75works0.32yr avg
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Research Topics

Immune Cell Function and Interaction(49), T-cell and B-cell Immunology(45), Immunodeficiency and Autoimmune Disorders(19), CAR-T cell therapy research(12), Immunotherapy and Immune Responses(9)

Publications75 total

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation
The Journal of Experimental Medicine·2026· 1 citedOpen Access
PI3Kδ promotes T cell effector differentiation and plasticity during chronic infection
2025Open Access
A PI3Kd-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling 4854
The Journal of Immunology·2025Open Access
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4 <sup>+</sup> T helper cell signaling, differentiation and epigenetic remodeling
2024Open Access
TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation
Immunity·2023· 98 citedOpen Access
PI3Kdelta coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells differentiation
The Journal of Immunology·2023Open Access
PI3Kδ: a key driver of effector differentiation under conditions of T cell exhaustion
The Journal of Immunology·2023Open Access
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells
Science Signaling·2022· 28 citedOpen Access
The Road Less Taken: Less Appreciated Pathways for Manipulating CD8+ T Cell Exhaustion
Frontiers in Immunology·2022· 11 citedOpen Access
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
Cell Reports·2021· 28 citedOpen Access
PI3Kd coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells at the expense of memory
The Journal of Immunology·2021
T and B‐cell signaling in activated PI3K delta syndrome: From immunodeficiency to autoimmunity
Immunological Reviews·2019· 84 cited
Mg2+ regulation of kinase signaling and immune function
The Journal of Experimental Medicine·2019· 81 cited
PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity
Frontiers in Immunology·2019· 40 citedOpen Access
Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity
Nature Immunology·2018· 89 citedOpen Access
Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function
Frontiers in Immunology·2018· 34 citedOpen Access
X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective
Frontiers in Immunology·2018· 75 citedOpen Access
SAP and Lessons Learned from a Primary Immunodeficiency
The Journal of Immunology·2017· 5 citedOpen Access
A delicate balance of PI3K activation is required for CD8 T cell survival and generation of memory cells
The Journal of Immunology·2017
Dissecting the role of Phosphotidylinositol 3-Kinase (PI3K) δ in the germinal center reaction through a mouse model of hyperactivated <i>Pik3cd</i>
The Journal of Immunology·2017
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Frequent Co-authors

Pamela L. Schwartzberg(40), Julio Gómez‐Rodríguez(7), Tania H. Watts(7), Silvia Preite(6), Stuart G. Tangye(5), Kristina T. Lu(5), Robin Handon(5), Gülbû Uzel(4), Kim E. Nichols(4), Alan Sher(4), Dragana Janković(4), Stacie M. Anderson(4), Bonnie Huang(4), Fang Zhao(3), Michael J. Lenardo(3), Hai Qi(3), Ronald N. Germain(3), Shane Crotty(3), Mala Dutta(3), Jun Cheng(3)