Lynn Colletti

AbbVie (United States) — United States

Medicine · Health Sciences

7h-index169citations8works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(7), HIV Research and Treatment(4), Hepatitis C virus research(3), HIV-related health complications and treatments(2), Biochemical and Molecular Research(2)

Publications8 total

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a <i>trans</i>-Stilbene Analog with Good Oral Bioavailability
Journal of Medicinal Chemistry·2018· 18 cited
High potency improvements to weak aryl uracil HCV polymerase inhibitor leads
Bioorganic & Medicinal Chemistry Letters·2013· 6 cited
2-Pyridyl P1′-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors (A-792611 and A-790742) with Potential for Convenient Dosing and Reduced Side Effects
Journal of Medicinal Chemistry·2009· 30 citedOpen Access
Methods to measure the intracellular concentration of unlabeled compounds within cultured cells using liquid chromatography/tandem mass spectrometry
Analytical Biochemistry·2008· 25 cited
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors
Bioorganic & Medicinal Chemistry·2006· 11 cited
Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir
Antimicrobial Agents and Chemotherapy·2004· 30 citedOpen Access
Design and synthesis of pseudo-Symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-Hydrazide isostere
Bioorganic & Medicinal Chemistry Letters·2003· 13 citedOpen Access
Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line
Life Sciences·2000· 36 cited

Frequent Co-authors

Warren M. Kati(6), Dale J. Kempf(4), John T. Randolph(4), Tatyana Dekhtyar(3), Kennan C. Marsh(3), Akhteruzzaman Molla(3), Yaya Liu(3), Gennadiy Koev(3), David A. DeGoey(2), Charles A. Flentge(2), William J. Flosi(2), Clinton M. Yeung(2), Larry L. Klein(2), Hongmei Mo(2), Rolf Wagner(2), Jill Beyer(2), Rubina Mondal(2), David W. A. Beno(2), Kenton L. Longenecker(2), Clarence J. Maring(2)