William J. Flosi

Abbott Fund — United States

Medicine · Health Sciences

7h-index229citations11works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(6), HIV Research and Treatment(5), Pneumocystis jirovecii pneumonia detection and treatment(4), Chemical Synthesis and Analysis(2), Bioactive Compounds and Antitumor Agents(2)

Publications11 total

P1-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors with Potent Antiviral Activity against Drug-Resistant Viruses
Journal of Medicinal Chemistry·2011· 9 citedOpen Access
Water-Soluble Prodrugs of the Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir
Journal of Medicinal Chemistry·2009· 37 cited
2-Pyridyl P1′-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors (A-792611 and A-790742) with Potential for Convenient Dosing and Reduced Side Effects
Journal of Medicinal Chemistry·2009· 30 citedOpen Access
Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742
Antimicrobial Agents and Chemotherapy·2008· 6 citedOpen Access
Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV
Bioorganic & Medicinal Chemistry·2006· 27 cited
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors
Bioorganic & Medicinal Chemistry·2006· 11 cited
Enantioselective Synthesis of Antiinfluenza Compound A‐315675 (I).
ChemInform·2002
Enantioselective Synthesis of Antiinfluenza Compound A-315675
The Journal of Organic Chemistry·2002· 95 cited
ChemInform Abstract: Synthesis of the 3a‐(3‐Indolyl)‐1,2,3,3a,8,8a‐hexahydropyrrolo[2,3‐b]indole Core of Leptosins D—F.
ChemInform·1998
Synthesis of the 3a-(3-Indolyl)-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole Core of Leptosins D-F
Heterocycles·1998· 14 citedOpen Access
Synthesis and Nucleophilic Addition Reactions of a Serine Derived Amino Aldehyde
Digital Commons at Illinois Wesleyan University (Illinois Wesleyan University)·1996Open Access

Frequent Co-authors

David A. DeGoey(8), Larry L. Klein(8), Dale J. Kempf(8), David J. Grampovnik(7), Akhteruzzaman Molla(5), Tatyana Dekhtyar(5), Clinton M. Yeung(4), Kennan C. Marsh(4), Hui-Ju Chen(3), Warren M. Kati(3), Charles A. Flentge(2), John T. Randolph(2), Lynn Colletti(2), Vincent S. Stoll(2), Mulugeta Mamo(2), Hongmei Mo(2), Sherie Masse(2), David Crich(2), Ewa Fredette(2), Xiu C. Wang(1)