Amy E. Fraley

Board of the Swiss Federal Institutes of Technology — Switzerland

Medicine · Health Sciences

12h-index646citations45works2.02yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(25), Microbial Metabolism and Applications(9), Alkaloids: synthesis and pharmacology(8), Plant-Microbe Interactions and Immunity(5), Genomics and Phylogenetic Studies(4)

Publications45 total

Biochemistry and Structure of Nonheme Iron and α‐Ketoglutarate‐Dependent Halogenases
Encyclopedia of Inorganic and Bioinorganic Chemistry·2025
Bio-Based Approaches for Selective Cyclization
CHIMIA International Journal for Chemistry·2025Open Access
Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member
Proceedings of the National Academy of Sciences·2024· 8 citedOpen Access
The 57<sup>th</sup> Burgenstock Conference
CHIMIA International Journal for Chemistry·2024Open Access
A mechanistic blueprint for enzymatic reduction by a modular polyketide synthase
Structure·2023Open Access
Front Cover: Characterization of an Unusual α‐Oxoamine Synthase Off‐Loading Domain from a Cyanobacterial Type I Fatty Acid Synthase (ChemBioChem 18/2023)
ChemBioChem·2023Open Access
Modular Oxime Formation by a <i>trans</i>‐AT Polyketide Synthase
Angewandte Chemie·2023
Modular Oxime Formation by a <i>trans</i>‐AT Polyketide Synthase
Angewandte Chemie International Edition·2023· 5 cited
Characterization of an Unusual α‐Oxoamine Synthase Off‐Loading Domain from a Cyanobacterial Type I Fatty Acid Synthase
ChemBioChem·2023· 1 citedOpen Access
Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation
Structure·2023· 3 cited
Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis
Angewandte Chemie·2022· 2 cited
Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis
Angewandte Chemie International Edition·2022· 7 citedOpen Access
Modular Halogenation, α‐Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase
Angewandte Chemie International Edition·2022· 24 cited
Modular Halogenation, α‐Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase
Angewandte Chemie·2022· 2 cited
Cover Feature: Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides (ChemBioChem 17/2020)
ChemBioChem·2020Open Access
CCDC 1973958: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
CCDC 1973959: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
CCDC 1973957: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Fungal-derived brevianamide assembly by a stereoselective semipinacolase
Nature Catalysis·2020· 85 citedOpen Access
Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides
ChemBioChem·2020· 33 citedOpen Access
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Frequent Co-authors

David H. Sherman(23), Robert M. Williams(20), Sean A. Newmister(19), Sachiko Tsukamoto(12), Robert S. Paton(11), Hikaru Kato(10), Vikram V. Shende(10), Shengying Li(10), Janet L. Smith(10), Jörn Piel(10), Roy A. Meoded(9), Cora L. Dieterich(8), Fengan Yu(7), Atsushi Minami(7), Maria L. Adrover‐Castellano(7), Nolan Carney(7), Samantha P. Kelly(7), Shuai Mu(6), Hideaki Oikawa(6), Qingyun Dan(6)