Sean A. Newmister

University of Michigan — United States

Medicine · Health Sciences

24h-index1.4kcitations85works3.82yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(34), Alkaloids: synthesis and pharmacology(11), Chemical synthesis and alkaloids(11), Pharmacogenetics and Drug Metabolism(9), Enzyme Structure and Function(9)

Publications85 total

Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA
Nature Communications·2026Open Access
An Evolutionarily Conserved Protein Fold with Multiple Roles in Anthracycline Biosynthesis
2025Open Access
Engineering a Biosynthetic Pathway to Produce (+)-Brevianamides A and B
ACS Catalysis·2025· 4 citedOpen Access
The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids
Chemical Reviews·2025· 11 citedOpen Access
Engineering a Biosynthetic Pathway for the Production of (+)-Brevianamides A and B in <i>Escherichia coli</i>
2024Open Access
Metabologenomics reveals strain-level genetic and chemical diversity of <i>Microcystis</i> secondary metabolism
mSystems·2024· 8 citedOpen Access
An NmrA-like enzyme-catalysed redox-mediated Diels–Alder cycloaddition with anti-selectivity
Nature Chemistry·2023· 28 citedOpen Access
Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases
Angewandte Chemie International Edition·2023· 27 citedOpen Access
Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases
Angewandte Chemie·2023· 4 citedOpen Access
CCDC 2180959: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C–H Functionalization and Epoxidation of Tirandamycin Antibiotics
ACS Catalysis·2021· 29 citedOpen Access
Structural Diversification of Hapalindole and Fischerindole Natural Products via Cascade Biocatalysis
ACS Catalysis·2021· 10 citedOpen Access
Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C-H Functionalization and Epoxidation of Tirandamycin Antibiotics
2021· 1 citedOpen Access
Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C-H Functionalization and Epoxidation of Tirandamycin Antibiotics
2021· 1 citedOpen Access
Molecular Basis of Iterative C–H Oxidation by TamI, a Multifunctional P450 Monooxygenase from the Tirandamycin Biosynthetic Pathway
ACS Catalysis·2020· 27 citedOpen Access
Cover Feature: Flavin‐Dependent Monooxygenases NotI and NotI′ Mediate Spiro‐Oxindole Formation in Biosynthesis of the Notoamides (ChemBioChem 17/2020)
ChemBioChem·2020Open Access
Structure and Function of NzeB, a Versatile C–C and C–N Bond-Forming Diketopiperazine Dimerase
Journal of the American Chemical Society·2020· 78 citedOpen Access
Molecular Basis of Iterative C–H Oxidation by TamI, a Multifunctional P450 Monooxygenase from the Tirandamycin Biosynthetic Pathway
2020· 4 citedOpen Access
Molecular Basis of Iterative C–H Oxidation by TamI, a Multifunctional P450 Monooxygenase from the Tirandamycin Biosynthetic Pathway
2020Open Access
CCDC 1973958: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
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Frequent Co-authors

David H. Sherman(34), Robert M. Williams(17), K. N. Houk(14), Fengan Yu(13), Amy E. Fraley(11), Vikram V. Shende(11), Yogan Khatri(10), Jacob N. Sanders(9), Ivan Rayment(8), Sachiko Tsukamoto(7), Kersti Caddell Haatveit(7), Hikaru Kato(6), Ashootosh Tripathi(6), Robert S. Paton(6), Shengying Li(6), Janet L. Smith(6), Shasha Li(6), Andrew N. Lowell(6), Marc Garcia‐Borràs(6), Samantha P. Kelly(5)