Aaron T. Wecksler

Medicine · Health Sciences

25h-index1.8kcitations43works0.32yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(12), Protein purification and stability(11), Advanced Proteomics Techniques and Applications(9), Eicosanoids and Hypertension Pharmacology(9), Mass Spectrometry Techniques and Applications(6)

Publications43 total

Footprinting for fingerprinting: proof-of-concept for the use of hydroxyl radical protein footprinting for structural comparison studies
mAbs·2025· 1 citedOpen Access
Modern Methods for Characterizing the <scp>Higher‐Order</scp> Structure ( <scp>HOS</scp> ) of Biotherapeutics
2025
Drug Delivery Modalities and Mechanisms
2025
Recommendations and Considerations for Hydroxyl Radical Protein Footprinting - Mass Spectrometry
2025Open Access
Bioprocess Development and Characterization of a 13C-Labeled Hybrid Bispecific Antibody Produced in Escherichia coli
Antibodies·2023· 2 citedOpen Access
Targeted degradation via direct 26S proteasome recruitment
Nature Chemical Biology·2022· 100 citedOpen Access
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms
mAbs·2022· 17 citedOpen Access
Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species
mAbs·2022· 25 citedOpen Access
Development of Software Workflow for the Rapid Detection of Cross-Linked Dipeptides
Journal of the American Society for Mass Spectrometry·2022· 2 cited
Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody
mAbs·2022· 18 citedOpen Access
Antibody–receptor interactions mediate antibody-dependent cellular cytotoxicity
Journal of Biological Chemistry·2021· 32 citedOpen Access
Optimizing Hydroxyl Radical Footprinting Analysis of Biotherapeutics Using Internal Standard Dosimetry
Journal of the American Society for Mass Spectrometry·2020· 11 cited
Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity
mAbs·2020· 29 citedOpen Access
Utilizing Multidimensional LC–MS for Hydroxyl Radical Footprinting Analysis
Archive ouverte UNIGE (University of Geneva)·2019· 2 cited
Current Trends in Biotherapeutic Higher Order Structure Characterization by Irreversible Covalent Footprinting Mass Spectrometry
Protein and Peptide Letters·2018· 6 cited
Structural basis for antagonism of bacterial LPS transport
Acta Crystallographica Section A Foundations and Advances·2018Open Access
Structural basis for dual-mode inhibition of the ABC transporter MsbA
Nature·2018· 173 cited
Monoclonal antibody targeting the β-barrel assembly machine of <i>Escherichia coli</i> is bactericidal
Proceedings of the National Academy of Sciences·2018· 176 citedOpen Access
Characterization of ELISA Antibody-Antigen Interaction using Footprinting-Mass Spectrometry and Negative Staining Transmission Electron Microscopy
Journal of the American Society for Mass Spectrometry·2018· 32 cited
Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody
Molecular Pharmaceutics·2018· 25 cited
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Frequent Co-authors

Galahad Deperalta(11), Bruce D. Hammock(10), Sung Hee Hwang(8), Natalie K. Garcia(7), Theodore R. Holman(7), Alavattam Sreedhara(6), Christophe Morisseau(4), Robert H. Weiss(4), Jian Payandeh(3), Inna Zilberleyb(3), Jun‐Yan Liu(3), Michael L. Gross(3), Hiromi I. Wettersten(3), Wilfred A. van der Donk(3), Mark R. Chance(3), Hoangdung Ho(2), Anh Miu(2), Mary Kate Alexander(2), Mike Reichelt(2), Christine Tam(2)