Christopher R. M. Asquith

University of North Carolina at Chapel Hill — United States

Materials Science · Physical Sciences

21h-index1.2kcitations163works1.02yr avg
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Research Topics

Crystallization and Solubility Studies(66), X-ray Diffraction in Crystallography(66), Quinazolinone synthesis and applications(21), Protein Kinase Regulation and GTPase Signaling(10), HIV/AIDS drug development and treatment(10)

Publications163 total

Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
UNC Libraries·2025Open Access
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma
UNC Libraries·2025Open Access
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors
UNC Libraries·2025Open Access
Identification of 4‐Anilinoquin(az)oline as a Cell‐Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype
UNC Libraries·2025Open Access
Small-molecule inhibition of the archetypal UbiB protein COQ8
UNC Libraries·2025Open Access
Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure
Molecular Metabolism·2025· 1 citedOpen Access
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
UNC Libraries·2025Open Access
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Nature Communications·2025· 2 citedOpen Access
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
UNC Libraries·2025Open Access
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies
UNC Libraries·2025Open Access
Synthesis and evaluation of 1,2,3-dithiazole inhibitors of the nucleocapsid protein of feline immunodeficiency virus (FIV) as a model for HIV infection
UNC Libraries·2025Open Access
Corrigendum to “Synthesis and evaluation of 1,2,3-dithiazole inhibitors of the nucleocapsid protein of feline immunodeficiency virus (FIV) as a model for HIV infection” [Bioorg. Med. Chem. 68 (2022) 116834]
UNC Libraries·2025Open Access
Utilization of Supervised Machine Learning to Understand Kinase Inhibitor Toxophore Profiles
UNC Libraries·2025Open Access
Medicinal chemistry applications of the Dimroth Rearrangement to the synthesis of biologically active compounds
European Journal of Medicinal Chemistry·2025· 1 citedOpen Access
TLK2: a target for cancer and viral latency
Nature Reviews Drug Discovery·2024
Pentathiepins are an understudied molecular prism of biological activities
Archiv der Pharmazie·2024· 5 citedOpen Access
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
2024· 2 citedOpen Access
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
European Journal of Medicinal Chemistry·2024· 3 citedOpen Access
Enhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy
Scientific Reports·2024· 5 citedOpen Access
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships
2023· 1 citedOpen Access
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Frequent Co-authors

Tuomo Laitinen(24), William J. Zuercher(19), Michael P. East(13), Carrow I. Wells(12), Timothy M. Willson(10), Antti Poso(10), Jonathan M. Elkins(8), David H. Drewry(7), James M. Bennett(7), Lidia S. Konstantinova(7), Олег А. Ракитин(7), Regina Hofmann‐Lehmann(7), Daniel J. Crona(6), Chad Torrice(6), Stephen T. Hilton(6), Graham J. Tizzard(6), Gary L. Johnson(5), Shirit Einav(5), Stefan Knapp(4), Susanne Müller(4)