Christopher E. Heise

Neuroscience · Life Sciences

29h-index5.5kcitations55works16.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(10), Receptor Mechanisms and Signaling(9), Biochemical Analysis and Sensing Techniques(9), Regulation of Appetite and Obesity(7), Sphingolipid Metabolism and Signaling(7)

Publications55 total

The discovery and structural basis of two distinct state-dependent inhibitors of BamA
Nature Communications·2024· 16 citedOpen Access
Lipid Tales: Optimizing Arylomycin Membrane Anchors
ACS Medicinal Chemistry Letters·2023· 4 citedOpen Access
Optimized arylomycins are a new class of Gram-negative antibiotics
Nature·2018· 349 cited
Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models
Frontiers in Molecular Neuroscience·2018· 35 citedOpen Access
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission
Nature Communications·2017· 40 citedOpen Access
Structural and Functional Organization of the Postsynaptic Density☆
Elsevier eBooks·2016· 1 cited
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase
mBio·2016· 19 citedOpen Access
Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2016· 18 citedOpen Access
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
Journal of Medicinal Chemistry·2016· 74 citedOpen Access
The differential role of cortical protein synthesis in taste memory formation and persistence
npj Science of Learning·2016· 22 citedOpen Access
Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus
Frontiers in Cellular Neuroscience·2016· 54 citedOpen Access
eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures
Cerebral Cortex·2016· 68 citedOpen Access
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p <i>K</i> <sub>a</sub> Polar Moiety
ACS Medicinal Chemistry Letters·2015· 81 citedOpen Access
Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors
Bioorganic & Medicinal Chemistry Letters·2015· 18 citedOpen Access
Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors
Journal of Medicinal Chemistry·2015· 37 citedOpen Access
Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series
ACS Medicinal Chemistry Letters·2015· 13 citedOpen Access
Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity
Philosophical Transactions of the Royal Society B Biological Sciences·2014· 46 citedOpen Access
Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors
Journal of Medicinal Chemistry·2014· 63 citedOpen Access
Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons
Frontiers in Cellular Neuroscience·2014· 99 citedOpen Access
List of Contributors
Elsevier eBooks·2014
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Frequent Co-authors

David Schwarz(11), Val S. Goodfellow(10), Kevin R. Lynch(8), Weiru Wang(8), Carlo Sala(8), James J. Crawford(7), Brian Dyck(7), Junko Tamiya(7), Jonathan Grey(7), Martin W. Rowbottom(7), Troy Vickers(7), Dong‐Soon Im(6), Robert Mintzer(6), Lionel Rougé(6), Chiara Verpelli(6), Klaus P. Hoeflich(6), Joachim Rudolph(6), Brian F. O’Dowd(5), Ignacio Aliagas(5), Hank La(5)