Marta Filizola

Icahn School of Medicine at Mount Sinai — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index9.3kcitations264works3.62yr avg
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Research Topics

Receptor Mechanisms and Signaling(159), Neuropeptides and Animal Physiology(95), Pharmacological Receptor Mechanisms and Effects(30), Computational Drug Discovery Methods(29), Cell Adhesion Molecules Research(29)

Publications264 total

Structural and dynamic studies uncover a distinct allosteric modulatory site at the μ-opioid receptor
2025Open Access
BOLD-GPCRs: A Transformer-Powered App for Predicting Ligand Bioactivity and Mutational Effects Across Class A GPCRs
2025Open Access
Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins
Nature Communications·2025· 3 citedOpen Access
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β <sub>2</sub> ‐Adrenoceptor
Angewandte Chemie·2025Open Access
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β <sub>2</sub> ‐Adrenoceptor
Angewandte Chemie International Edition·2025· 1 citedOpen Access
Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs
Biochemistry·2025· 3 citedOpen Access
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
Nature Communications·2025· 38 citedOpen Access
BPS2025 - Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins
Biophysical Journal·2025
Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs
2024Open Access
Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins
2024Open Access
Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
Nature Communications·2024· 2 citedOpen Access
Can Targeting the Sodium Site via Water Molecules Lead to the Development of Safer Opioids?
ACS Central Science·2024· 2 citedOpen Access
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization
Nature Communications·2024· 12 citedOpen Access
De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework
UNC Libraries·2024Open Access
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects
UNC Libraries·2024Open Access
A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects
UNC Libraries·2024Open Access
Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT <sub>1e</sub> R and 5-HT <sub>1F</sub> R
Science Advances·2024· 6 citedOpen Access
Author Correction: Structural basis for partial agonism in 5-HT3A receptors
Nature Structural & Molecular Biology·2024· 3 citedOpen Access
Leveraging protein language models and graph convolutional neural networks for accurate prediction of ligand bioactivity in class A G protein-coupled receptors
Biophysical Journal·2024Open Access
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization
Biophysical Journal·2024· 1 citedOpen Access
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Frequent Co-authors

Davide Provasi(20), Jonathan A. Javitch(8), Harel Weinstein(8), Lakshmi A. Devi(6), Abhijeet Kapoor(6), Ana Negri(6), Jennifer M. Johnston(5), Yi Shang(5), Graeme Milligan(4), Martin J. Lohse(4), Jean‐Philippe Pin(3), Juan Carlos Mobarec(3), George Khelashvili(3), Sandip Basak(3), Sudha Chakrapani(3), Barry S. Coller(3), Toni Giorgino(2), Javier González‐Maeso(2), Stuart C. Sealfon(2), Wen Guo(2)