Kaustav Biswas

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index1.6kcitations59works11.32yr avg
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Research Topics

Chemical Synthesis and Analysis(18), Coagulation, Bradykinin, Polyphosphates, and Angioedema(11), Synthetic Organic Chemistry Methods(8), Cancer Treatment and Pharmacology(8), Neuropeptides and Animal Physiology(7)

Publications59 total

Integrated <i>In Silico</i>, <i>Ex Vivo</i>, and <i>In Vitro</i> Framework for Early Derisking of Mast Cell Degranulation in Peptide Drug Candidates
Chemical Research in Toxicology·2025
Author Correction: Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Nature Communications·2025Open Access
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Nature Communications·2024· 35 citedOpen Access
Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts
Scientific Reports·2023· 19 citedOpen Access
Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
2023· 2 citedOpen Access
Development of a high-throughput barrier function assay using primary human gut organoids
2022Open Access
Rapid label-free cell-based Approach Membrane Permeability Assay using MALDI-hydrogen-deuterium exchange mass spectrometry for peptides
Analytica Chimica Acta·2022· 12 cited
Preface
ACS symposium series·2022
Peptide Drug Discovery<i>Raison d’Etre</i>: Engineering Mindset, Design Rules and Screening Tools
ACS symposium series·2022· 7 cited
Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology
Journal of Medicinal Chemistry·2022· 26 citedOpen Access
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling
2021· 2 citedOpen Access
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay
ACS Chemical Biology·2021· 57 cited
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling
Chemical Science·2021· 31 citedOpen Access
Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
Drug Metabolism and Disposition·2019· 6 cited
Engineering Na<sub>V</sub>1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics
ACS Chemical Biology·2019· 16 cited
Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1
ACS Chemical Biology·2018· 15 cited
Discovery of Tarantula Venom-Derived Na<sub>V</sub>1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis
Journal of Medicinal Chemistry·2018· 31 citedOpen Access
Discovery of TRPM8 Antagonist (<i>S</i>)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Journal of Medicinal Chemistry·2018· 60 citedOpen Access
Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V
PLoS ONE·2018· 49 citedOpen Access
CCDC 1841307: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
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Frequent Co-authors

Jian Jeffrey Chen(11), Samuel J. Danishefsky(9), Jennifer R. Allen(9), Les P. Miranda(9), Randall W. Hungate(9), Ruchia Duggal(8), Tomi K. Sawyer(8), Leyla Arik(8), Eileen Johnson(8), Kristin L. Andrews(7), Qingyian Liu(7), Anthony W. Partridge(7), Justin K. Murray(7), Joseph Ligutti(7), Bryan D. Moyer(7), Benny C. Askew(7), Andrea Peier(6), Lan Ge(6), Christopher J. Brown(6), Charles W. Johannes(6)