Jana Miniarikova

Leiden University Medical Center — Netherlands

Neuroscience · Life Sciences

7h-index604citations14works0.02yr avg
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Research Topics

Genetic Neurodegenerative Diseases(9), RNA Research and Splicing(6), CRISPR and Genetic Engineering(6), Viral Infectious Diseases and Gene Expression in Insects(3), Mitochondrial Function and Pathology(2)

Publications14 total

Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system
Brain Communications·2021· 6 citedOpen Access
Transfer of Therapeutic miRNAs Within Extracellular Vesicles Secreted from Huntington’s Disease iPSC-derived Neurons (4548)
Neurology·2020· 4 cited
Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
Molecular Therapy — Nucleic Acids·2019· 91 citedOpen Access
Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients
Molecular Therapy — Nucleic Acids·2019· 58 citedOpen Access
MicroRNA-based gene therapy for Huntington's disease : Silencing the villain
Leiden Repository (Leiden University)·2019Open Access
I04 AAV5-MIHTT gene therapy demonstrates broad distribution and strong human mutant huntingtin lowering in a huntington disease minipig model
2018
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model
Molecular Therapy·2018· 157 citedOpen Access
Translation of MicroRNA-Based Huntingtin-Lowering Therapies from Preclinical Studies to the Clinic
Molecular Therapy·2018· 42 citedOpen Access
AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease
Gene Therapy·2017· 100 citedOpen Access
Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing
Molecular Therapy — Methods & Clinical Development·2017· 15 citedOpen Access
L4 Sustained and strong HTT silencing by AAV5-miHTT as therapy for huntington’s disease
Journal of Neurology Neurosurgery & Psychiatry·2016
L5 Pre-clinical evaluation of aav5-mihtt gene therapy of huntington’s disease in rodents
Journal of Neurology Neurosurgery & Psychiatry·2016
Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease
Molecular Therapy — Nucleic Acids·2016· 131 citedOpen Access
M01 Rnai-based Gene Therapy Of Huntington's Disease
Journal of Neurology Neurosurgery & Psychiatry·2014

Frequent Co-authors

Pavlina Konstantinova(12), Melvin M. Evers(10), Harald Petry(9), S J van Deventer(7), Bas Blits(5), Raygene Martier(5), Cynthia Brouwers(4), Nicole Déglon(4), Astrid Vallès(3), Jacek Lubelski(3), Jan Motlík(3), Amber L. Southwell(3), Virginie Zimmer(3), Sander van Deventer(3), Štefan Juhás(2), Božena Bohuslavová(2), Jana Juhásová(2), Helena Kupcová Skalníková(2), Petr Vodička(2), Ivona Valeková(2)